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Diabetes management in general practiceDiabetes
Guidelines for Type 2 Diabetes An electronic version of these guidelines is available at
Any changes after the printing of this edition and before the next will be available on this website. This booklet is intended to provide information about the management of type 2 diabetes in Australian general practice. However, type 1 diabetes is mentioned in several sections. General practitioners seeking information about the management of type 1 diabetes should consult other sources. This booklet is not intended to replace professional judgement, experience and appropriate referral. While every care has been taken to ensure accuracy, reference to product information is recommended before prescribing. Diabetes Australia and the RACGP assume no responsibility for personal or other injury, loss or damage that may result from the information in this publication. DIABETES MANAGEMENT Seventeenth edition 2011/12 supporting the education programs of Diabetes Australia Gratitude is expressed to everybody who has contributed to these guidelines: The Health Care and Education Committee of Diabetes Australia, The Australian Diabetes Educators Association, Australian Diabetes Society, Dietitians Association of Australia, The Australian Podiatry Council, many general practitioners, endocrinologists, dietitians, diabetes educators and podiatrists.
Dr Peter Harris
Senior Lecturer School of Public Health and Community Medicine, University of New South Wales, Sydney NSW
Dr Linda Mann
Leichhardt, Sydney NSW; Medical Educator, GP Synergy; RACGP Representative on Editorial Panel
Dr Pat Phillips
Manager, Clinical Improvement Unit Royal Australian College of General Practitioners
National Publications Manager State and Territory Diabetes Organisations Appreciation is expressed to Dr Michael d'Emden, Chair of the Health Care and Education Committee of Diabetes Australia and to Dr Evan Ackermann, Chair of the RACGP National Standing Committee – Quality Care. Both Committees have reviewed and endorsed this publication until 2012. Appreciation is also expressed to Dr Chris Holmwood who prepared the original guidelines. The Editors have considered and included relevant information within guidelines and evidence recognised by the medical profession, including the NHMRC and the Australian Diabetes Society. This document is designed for first line primary care. More complex care is best addressed by a team.
ISBN: 978 1875690 190 July 2011Photocopying this publication in its original form is permitted for educational purposes only. Reproduction in any other form without the written permission of Diabetes Australia is prohibited.
Printed July 2011 – Copyright Diabetes Australia 2011 2 Diabetes Management in General Practice Update on what was new, changed or controversial in 2010/11 What's changed in this edition? Who needs to be tested for undiagnosed diabetes? What type of diabetes? Initial assessment Plan of continuing care 3 The team approach Members of the team Counselling the person with diabetes 4 initial management Physical activity 5 Health care for diabetes Medical monitoring 5.2.1 Quarterly review
22.214.171.124 Quarterly nursing review
5.2.2 Annual review
126.96.36.199 Annual nursing review
Systems for care 5.3.1 How Medicare supports the process
5.3.2 Required annual cycle of care
5.3.3 General Practice Management Plans (GPMP)
5.3.4 Team Care Arrangements (TCA)
Oral hypoglycaemic agents Insulin treatment Insulin delivery Insulins available Problems with medication Surgical procedures 8 Hyperglycaemic emergencies Diabetic ketoacidosis Hyperosmolar non-ketotic coma 9 Factors complicating management Macrovascular disease Problems with medications Complementary medicines 10 Diabetes and reproductive health 10.1 Pregnancy
10.2 Gestational diabetes
10.4 Hormone replacement therapy
10.5 Sexual problems
13 Diabetes australia 14 National Diabetes services scheme (NDss) 15 Royal australian College of General Practitioners Further resources internet resources Goals for management 4 Diabetes Management in General Practice ForewordGeneral practitioners continue to provide most of the medical care to people with type 2 diabetes. The complexity of care for this common disease requires systematic care from the practice team and the timely referral to community and hospital based specialists.
The current guide, in its seventeenth edition, plays an important role in providing a readable summary of current guidelines and recommendations from various sources on the management of type 2 diabetes in adults in the general practice setting. Importantly, this edition again includes specific issues relating to treating diabetes in the Aboriginal and Torres Strait Islander population which reflect the burden of this disease within this group. Also included is a routine care checklist for practice nurses for use under the clinical oversight of the general practitioner.
Patricia McKenzie Professor Claire Jackson Royal Australian College of General Practitioners Update on what was new, changed or controversial in 2010/11 HbA1c
Diagnosis: The American Diabetes Association recommends HbA1c as well as
venous plasma glucose levels to diagnose type 2 diabetes with diagnostic values being ≥6.5%. This policy may be adopted in Australia in future.
Reporting: Internationally there is a move towards a standard based on the
chemistry of HbA1c which would result in reported values being considerably lower (by approximately 2%, eg: as 6% instead of 8%). If this change in standards is adopted in Australia both the old and the new values will be reported.
Aspirin and protection from cardiovascular disease
Similarly the controversy continues about the use of aspirin in reducing cardiovascular
events in those with type 2 diabetes but without evidence of cardiovascular disease. Until results of the International Prospective Randomised Controlled Trial are available, it is suggested that doctors consider prophylactic aspirin (75–325 mg) daily unless there are contraindications (refer pages 16, 56–57) and Goals for Management (tear out card and the outside back cover).
What's changed in this edition? Section 2, page 22: Targets for glycaemic control in type 2 diabetes. Pre prandial targets are now:• Normoglycaemia 4.0–6.0 mmol/L• NHMRC values 6.1–8.0 mmol/Lreflecting the need to individualise glycaemic targets. Reference is made to the Australian Diabetes Society Position Statement which offers guidelines for targets in patients in various clinical situations.
Evaluation of 2010/11 edition
RACGP carried out an evaluation of the 2010/11 edition. In general, feedback
was positive and there were also many suggested improvements which will be considered for future editions. We appreciate the input from participants in the evaluation and would welcome feedback from users of the 2011/12 edition (email to firstname.lastname@example.org).
6 Diabetes Management in General Practice This booklet is a guide to type 2 diabetes in adults.
Type 2 diabetes is a chronic condition which can result in disability and early death. Management of the person with diabetes requires the skills of several professionals (general practitioner, specialist physician, diabetes educator, podiatrist, dietitian, ophthalmologist or optometrist, exercise professional and dentist) and the active participation of the patient.
The aim of this booklet is to provide guidelines for management of type 2 diabetes. We hope that general practitioners will consult these guidelines in order to ensure a high standard of care for their patients.
• The underlying aim is improvement in the duration and quality of
life of patients.
• Encourage patients to participate and take an active role in the
management of their diabetes.
• Ensure that all other preventive health care activities are included,
while maintaining good diabetes health care.
Any guideline should be flexible: management takes into consideration the patient's age, educational level, cultural background, the current scientific knowledge, the availability of resources and the range of particular preferences of the patient and professionals involved.
The overall goals in degree of control and lifestyle modification must be realistic. The general practitioner can have an important positive effect on patient lifestyle. Education of a partner or other responsible carers is an important factor in maintaining positive lifestyle changes in a patient. Similarly the general practitioner can ensure that management is individualised to the person's cultural, educational and financial status.
The general practitioner is a key member of the therapeutic team. In many instances the general practitioner is the principal medical professional in the vast majority of patients. In other instances there may be a ‘shared-care' arrangement between specialist and general practitioner, while in others, management of diabetes by the specialist may be preferable. In all situations the paramount consideration is the patient's Specific issues relating to the treatment of diabetes in the Aboriginal and Torres Strait Islander population will be highlighted in boxes throughout the guidelines. A conservative approach has been taken on the statements included to ensure that practitioners can have confidence they are based on solid evidence.
For the team approach to be successful there should be good communication between members based on trust and respect. For example, the patient will often relate best to the general practitioner. The other team members should be able to support that relationship and channel their input to management accordingly.
The role of the general practitioner ideally involves initial diagnosis, treatment, coordination of consultant and allied professional care and continuing management (including education and counselling of the patient and carers).
• The importance of the patient-doctor partnership in the management of diabetes cannot be overstated. The patient and the general practitioner need to have an agreed understanding of the patient's diabetes and associated problems and agree on the management strategies being adopted.
• In order to provide optimum care, the general practitioner must have adequate records and systems in place which will assist in the recall of patients for further investigations or continuing management. Adequate records are also necessary in order to monitor outcomes – both for the individual and within the wider community. A diabetes register at every practice is encouraged.
• Ensure that all other preventive health care activities are included, while maintaining good diabetes health care.
Carers need to become involved in education and management decisions. This is particularly so in young people with diabetes, disabled patients and where major dietary changes are required. Every carer needs to be well informed on recognition and treatment of hypoglycaemia, if the patient is treated with insulin, sulphonylureas or repaglinide.
8 Diabetes Management in General Practice People in high risk groups need to be screened for undiagnosed type 2
diabetes. See following page for high risk categories.
A three-step screening and diagnosis procedure is recommended for detecting undiagnosed type 2 diabetes:1. Initial risk assessment using a risk assessment tool or risk factors2. Measurement of fasting plasma glucose3. Sometimes an oral glucose tolerance test (OGTT).
Diagnosis must be confirmed on a subsequent day unless unequivocal hyperglycaemia with acute metabolic decompensation or obvious symptoms are present.
The OGTT is unnecessary to diagnose diabetes in people with an unequivocally elevated fasting or random plasma glucose. An OGTT needs to be performed in a person with an equivocal result. (See Fig. 1).
The test is carried out after an overnight fast, following three days of adequate carbohydrate intake (greater than 150 g per day). A 75 g load of oral glucose is given and the diagnosis of diabetes can be made if venous plasma glucose level fasting is ≥7.0 mmol/L or 2-hour post glucose load is ≥11.1 mmol/L.
Capillary blood glucose measurement using a desktop meter may be used for
testing for undiagnosed diabetes as long as it is confirmed by venous plasma
measurement. Urine testing is not sufficiently sensitive or specific as a screening
test for undiagnosed diabetes.
Fig. 1: Glucose levels – venous plasma: mmol/L
Diabetes unlikely Diabetes uncertain Re-test yearly if Oral glucose tolerance test 3 yearly if 2-hour glucose levels increased risk Diabetes unlikely Impaired glucose tolerance Who needs to be tested for undiagnosed diabetes? Asymptomatic people at high risk of undiagnosed diabetes should be identified. One population-based tool is the AUSDRISK tool (www.health.gov.au) which is recommended for use every 3 years in all adults over the age of 40 as a screening tool to identify those at increased risk of having undiagnosed type 2 diabetes or of developing the disease in the next 5 years. To help prevent diabetes, some Divisions of General Practice offer programs to patients with high scores.
High risk individuals should be screened by measurement of plasma glucose. This needs to be performed in a laboratory (rather than using a blood glucose meter).
In addition to those identified by the AUSDRISK tool, people at high risk for undiagnosed type 2 diabetes are:• People with impaired glucose tolerance, impaired fasting glucose (see below).
• Aboriginal and Torres Strait Islanders aged 35 and over.
• Certain high risk non-English speaking people aged 35 and over (specifically Pacific Islanders, people from the Indian subcontinent, people of Chinese origin).
• People aged 40 and over who have one or more of the following risk factors: – Obesity (BMI ≥30 kg/m2) • All people with clinical cardiovascular disease (myocardial infarction, angina, stroke or peripheral vascular disease).
• Women with polycystic ovarian syndrome who are obese.
• People on antipsychotic drugs.
The following groups are also at high risk but further studies are required to evaluate net clinical or economic benefit:• Women with a history of gestational diabetes.
• People aged 55 and over.
• People aged 45 and over, with a first degree relative with type 2 diabetes.
Certain medications (especially glucocorticoids and atypical antipsychotics) can affect glucose metabolism and increase the risk of diabetes. Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT)
At-risk patients include those who:
• are over 40 years
• are overweight (particularly those with central adiposity), or
• have high blood pressure, known cardiovascular disease, a family history of
diabetes or past history of gestational diabetes. 10 Diabetes Management in General Practice Type 2 diabetes or impaired glucose tolerance (IGT) cannot be excluded in a patient with a random glucose of >5.5 mmol/L and <11.1 mmol/L. In such patients an OGTT should be performed to establish a diagnosis.
Fasting plasma glucose level ≥6.1 mmol/L but <7.0 mmol/L (impaired fasting
glucose [IFG]), or 2-hour glucose level following a 75 g glucose load ≥7.8 mmol/L but <11.1 mmol/L (impaired glucose tolerance [IGT]). Over 16% of the Australian population over the age of 25 years have either IGT or IFG.
Significance of IFG and IGT
Although originally considered to be 'pre-diabetes', indicating risk of future
diabetes, there is now evidence of a continuum of cardiovascular risk associated with dysglycaemia and early insulin resistance through IFG/IGT to the diabetic state. A close association between impaired glucose control not reaching the threshold for diagnosis of diabetes and the development of cardiovascular disease (CVD) has been described. CVD risk is distributed across a continuum of post-challenge glucose levels, making it likely that any degree of post-challenge hyperglycaemia is associated with the development of premature CVD.
Management of IFG and IGT
Patients with IFG/IGT must be counselled that they are at increased risk of
CVD, and strict control of all cardiovascular risk factors (blood pressure, lipids, smoking) should be a priority. Dietary and exercise advice should be given and aspirin therapy should be considered. Patients should be counselled about the increased risk of progression to diabetes, and advised of the results of recent diabetes prevention studies that have shown that lifestyle change (diet together with at least 150 minutes of exercise per week to achieve a weight loss of 7%) can delay or prevent progression to type 2 diabetes. Increased physical activity is particularly important in maintaining weight loss. Regular physical activity, including resistance activities, also improves insulin sensitivity; reduces plasma levels of insulin in people with hyperinsulinaemia; improves dyslipidaemia and lowers blood pressure. Moreover, physical activity increases metabolically active muscle tissue, improves general cardiovascular health and also reduces the risk of type 2 diabetes.
Whilst use of metformin and glitazones have been trialled as pharmacological approaches to diabetes prevention in this group with some success, lifestyle modification is more effective. Drug therapy is not approved for the treatment of impaired glucose tolerance and impaired fasting glucose. Periodic testing for undiagnosed diabetes is recommended in high risk individuals. All high risk people with a negative screening test are at risk of cardiovascular disease and the future development of type 2 diabetes, and need to be given appropriate advice on SNAP risk factor reduction (Smoking, Nutrition, Alcohol and Physical activity).
Pregnant women need to be screened for gestational diabetes (see section 10.2 on page 72).
Routine testing of low risk asymptomatic people is not recommended.
The Aboriginal and Torres Strait Islander population has a higher risk of developing diabetes and is 10.5 to 13 times more likely to die from diabetes, compared with non-Indigenous Australians. The prevalence of undiagnosed diabetes in the Aboriginal and Torres Strait Islander population exceeds 5% in all those over 35 years of age. In some regions the prevalence approaches 5% at a much younger age (as young as 18 years). The prevalence of diabetes risk factors including impaired glucose tolerance (IGT) exceeds 5% in this population aged under 35 years of age. The incidence of diabetes in the Aboriginal and Torres Strait Islander population is 10 times higher than the general population and reaches 2% per year in some regions (eg: Central Australia). What type of diabetes? Differentiation is based on age, rate of clinical onset, body weight,
family history and urinary ketones.
Once a diagnosis is made it is important to determine the type of diabetes. Usually there is clear clinical evidence and differentiation is easy.
– Young (generally) – Rapid onset
– Middle-aged (generally) – Slow onset – Ketosis prone
– Insulin deficient – Not prone to ketosis
– Insulin resistant – Recent weight loss
– Strong family history At present there are no practical or specific markers for either group. While type 1 diabetes occurs in the young it is by no means confined to that group. Similarly while many people with type 2 diabetes are overweight, some are normal weight. In fact, most overweight people do not develop diabetes.
Remember that someone treated with insulin does not necessarily have type 1 diabetes. In fact, if insulin is started several years after diagnosis, it is likely that the person has type 2 diabetes.
12 Diabetes Management in General Practice Type 1 diabetes
This type of diabetes was previously known as Insulin Dependent Diabetes
Mellitus (IDDM) or Juvenile Onset Diabetes. All patients should be suspected as type 1 until you can convince yourself otherwise. A simple urine dipstick can be used. If ketones are present, type 1 diabetes is highly likely. All children who are symptomatic should have a urine test or finger prick. If positive for glucose, urgent referral to hospital is needed (formal pathology is not required).
Late-onset Autoimmune Diabetes in Adults
There is a form of late onset diabetes that is autoimmune and requires treatment
with insulin within a relatively short period after diagnosis (often in the next 2 years). This is known as Late-onset Autoimmune Diabetes in Adults (LADA). These people tend to be young (30–40 years) and have a personal and/or family history of other autoimmune diseases (eg: hypo or hyperthyroidism). Testing for glutamic acid decarboxylase (GAD) antibodies can confirm the diagnosis and can prompt counselling the person about the likely time course of diabetes progression and the possibility of other autoimmune disease.
Type 2 diabetes
This type of diabetes was previously known as Non-Insulin Dependent Diabetes
Mellitus (NIDDM) or Maturity Onset Diabetes. However, type 2 diabetes can occur in children and adolescents if they are overweight or obese, have a family history of type 2 diabetes and/or come from a high risk group. Most people with newly diagnosed type 2 diabetes have few or no symptoms. Gestational diabetes
This type of diabetes occurs during pregnancy and is discussed on page 72.
Medication induced diabetes
Some medications, for example prednisolone and olanzapine, can produce
hyperglycaemia which can be associated with abnormal OGTT and the diagnosis of diabetes. This may require hypoglycaemic medication. Such patients require the usual diabetes assessment and management. When the medication is ceased, the requirement for hypoglycaemic treatment may change, but patients should still be considered to have diabetes and require ongoing cardiovascular monitoring. They are also at risk of developing frank diabetes again. Other forms of diabetes
These are uncommon but include cystic fibrosis, other causes of pancreatic injury
Initial assessment Assessment includes appraisal of cardiovascular risks and
A detailed assessment needs to be made at first diagnosis.
Predisposition to diabetes:
– Family history – Cultural group – Physical inactivity – Hypertension – Obstetric history of large babies or gestational diabetes – Medication causing hyperglycaemia – Personal or family history of haemochromatosis – Autoimmune disease (personal – Malaise/fatigue and/or family history of other – Altered vision autoimmune diseases (eg: hypo or hyperthyroidism)) Risk factors for complications
General symptom review
– Personal or family history of – Cardiovascular symptoms cardiovascular disease – Neurological symptoms – Bladder and sexual function – Hypertension – Foot and toe problems – Dyslipidaemia – Recurrent infections (especially urinary and skin) Lifestyle issues:
– Physical activity 14 Diabetes Management in General Practice Weight/waist: – Body Mass Index (BMI) = weight (kg) divided by – Waist circumference (see page 23) Cardiovascular system: – Blood pressure, ideally lying and standing – Peripheral, neck and abdominal vessels – Visual acuity (with correction) – Retinopathy (examine with pupil dilation) – Sensation and circulation – Skin condition – Pressure areas – Interdigital problems – Abnormal bone architecture Peripheral nerves: – Tendon reflexes – Sensation: touch (eg: with 10 g monofilament) vibration (eg: with 128 hz tuning fork) Urinalysis: – Nitrites and/or leucocytes Baseline: – Renal function: plasma creatinine (eGFR), – Lipids: LDL-C, HDL-C, total cholesterol, – Glycaemia: glycated haemoglobin (HbA1c) – ECG, if >50 years old and at least one other vascular – Microurine if high risk group (woman, neuropathy, – Thyroid function tests if there is a family history or clinical suspicion Plan of continuing care • Relieve acute symptoms.
• Optimise control of glycaemia and other risk factors for
• Treat existing complications.
• Maintain other preventive activities.
Priorities of management
Patient and carer counselling includes identifying and addressing concerns which may
be causing distress and adversely affecting management.
If the patient is symptomatic then treatment of hyperglycaemia needs to be prompt but if the patient is asymptomatic initial treatment can be more relaxed. The long term medical goal is the prevention of complications.
Control of blood pressure and dyslipidaemia are important as well as glycaemic control in preventing complications. The overall aim of management is to improve quality of life and prevent premature death:Short term:• Relief of symptoms and acute complicationsLong term:• Achievement of appropriate glycaemia• Reduction of concurrent risk factors• Identification and treatment of chronic complications• Maintain other preventive activities (eg: immunisation) • All patients should be advised of the risks of smoking and offered
assistance with smoking cessation.
• Assess cardiovascular risk and consider low dose aspirin for
cardiovascular protection in high risk patients.
16 Diabetes Management in General Practice • Patients with type 1 diabetes need specialist assessment.
• All people with type 2 diabetes need to see an ophthalmologist or
optometrist initially and then at least every two years.
Initially and then as patient becomes more familiar with management,
as considered necessary by patient, doctor or diabetes educator.
Ideally initially, then as considered necessary by patient, doctor or dietitian.
• Children, adolescents and adults with type 1 diabetes if the general practitioner
is not confident with management.
• Pregnant women with established diabetes and women with gestational diabetes (see page 72 for screening recommendations).
• People with diabetes and uncontrolled hyperglycaemia or with Ophthalmologist or optometrist:
• Fundal examination (dilated pupils).
• The presence of cataracts needs to be checked.
– prepubertal children: referral at puberty – adults: referral at time of initial diagnosis – thereafter at least every two years.
Ideal y initial y, and then regularly if there is/are peripheral vascular disease, neuropathy,
skin and/or nail problems and if there is difficulty in cutting toenails. Consider referral to a high risk foot clinic if ulceration or intractable foot pain is present.
While Indigenous Australians are at high risk of many diseases and premature death, they are less likely to receive many aspects of preventive care. Identification of patients of Aboriginal and Torres Strait Islander background is critical for appropriately targeting interventions. GPs are encouraged to routinely ask all patients if they have Aboriginal and Torres Strait Islander background so that they may target this risk group effectively.
3 The team approach • Consider referral to a diabetes educator or dietitian for
consolidation of education.
• A podiatrist's help needs to be sought if neuropathy, peripheral
vascular disease, foot abnormality or calluses are present.
• Rebates for attendance at private dentists and exercise
professionals are available for patients under the Enhanced
Primary Care Program, as part of a Team Care Arrangement.
• Medicare subsidies are available for group education sessions
involving diabetes educators, dietitians and exercise physiologists.
In the team management of diabetes the patient is the central member.
For patients to be actively involved in their care they must understand the condition,
its effect on health and the practicalities of management. Good communication between team members is important so that advice is consistent and not confusing for the patient.
Members of the team The following professionals are important in the team approach to diabetes: Diabetes educator
The diabetes educator can often spend more time than the general practitioner has
available, consolidating the patient's knowledge and skills regarding eating plan, physical activity, self-monitoring, medication usage, foot care etc. The Australian Diabetes Educators Association (ADEA) has established a credential ing program. Qualified professionals are "ADEA Credentialled Diabetes Educators". If available, the services of a diabetes educator are useful in the early stages and a continuing liaison can be established.
The role of the dietitian in the management of diabetes is paramount. Lifestyle changes
alone (healthy food and regular exercise with ensuing weight loss) are sufficient for glycaemic control in the majority of patients with newly diagnosed type 2 diabetes. Recommendations should be individualised to maximise cooperation. Early referral to a dietitian is desirable to ensure detailed education on this most important aspect of management. If the general practitioner and practice nurse understand the principles of dietary advice, the dietary recommendations can be reinforced within the general practice.
18 Diabetes Management in General Practice Endocrinologist/diabetologist/paediatrician
The advice of a specialist physician may be valuable for people with complicated
problems related to diabetes – especially children, adolescents and adults with type 1 diabetes or diabetes in pregnancy. A shared care approach by general practitioner and specialist will provide the best combination of specialised expertise and continuity of care. In many cases the specialist will be part of an organised, multi-disciplinary diabetes care team which can provide a comprehensive diabetes education program.
When initiating a physical activity program in a patient who has been relatively
inactive, the help of a physiotherapist with a special interest in exercise routines or an exercise physiologist may be of benefit. Rebates for attendance at exercise physiologists are available for patients under the Enhanced Primary Care Program, as part of a Team Care Arrangement (see pages 32 to 36).
The general practitioner has the central role in coordinating management of the person
with diabetes and in education, counsel ing and softening the "technology/person interface" often felt by people with a chronic condition. The general practitioner is the point of first contact and usually assumes responsibility for overall management.
In many practices, the practice nurse is invaluable in establishing, managing and
implementing systems for diabetes care.
All people with diabetes need to be assessed regularly by an ophthalmologist
or optometrist. Optometrists may be more available than ophthalmologists in some areas and most bulk bill for their services. Early detection of retinopathy, before visual loss occurs, markedly improves prognosis for sight. Any deterioration in vision requires immediate referral back to the ophthalmologist.
Oral health professional
Dental and periodontal problems are common in people with diabetes who need
to see a dentist regularly (eg: yearly). Rebates for attendance at private dentists are available for patients under the Enhanced Primary Care Program, as part of a Team Care Arrangement (see pages 32 to 36). Pharmacist
Pharmacists are frequently consulted by members of the community about a wide
range of health issues. Pharmacists usual y know the health problems and prescribed The team approach 19 medications and can provide useful advice on medication usage and potential problems. A formal Home Medicines Review (HMR) can be arranged by general practitioners (see page 33).
The podiatrist renders expert preventive care. If there is evidence of neuropathy,
macro vascular disease, anatomical problems or a previous foot problem, early referral is desirable and regular review is necessary. Foot complications account for over 50% of hospital bed days occupied by patients with diabetes and are the most common cause of non-traumatic amputation.
Aboriginal Health Workers
Where they are available, Aboriginal Health Workers (AHWs) have a key role in providing culturally appropriate and practical support and counselling, thus improving patient understanding and adherence to treatment programs.
Counselling the person with diabetes The diagnosis of diabetes can be very stressful for both younger and older patients. Initial denial of the condition (ie: a grief reaction) is normal. But if denial continues, diabetes care can be compromised.
Patients, whose difficulties with accepting the diagnosis compromise their treatment or who experience emotional or psychological distress, may benefit from Cognitive Behaviour Therapy or other psychological interventions. General practitioners can engage the help of a psychologist, social worker or counsellor. These practitioners may be accessed as part of a Team Care Arrangement within a General Practice Management Plan or under the Better Access to Psychiatrists, Psychologists and General Practitioners through the Medicare Benefits Scheme Initiative.
The younger patient should become familiar with the condition, insulin and diet and has to cope with feelings of dependence on medication for survival. The older patient faces increasing vulnerability to sickness, disability and loss of function. Fears may include job security, physical disfigurement and loss of ability to contribute to present relationships.
The diagnosis of diabetes may have a profound effect on people engaged in certain occupations, eg: machinery operators, pilots, heavy vehicle drivers, divers, etc. While not always prohibiting many of these occupations, the diagnosis of diabetes may require careful career counselling.
20 Diabetes Management in General Practice Lifestyles which have been established for many years are not easy to change and health care professionals cannot expect immediate adherence to the plan of management. Assess the SNAP risk factors (Smoking, Nutrition, Alcohol and Physical activity) and establish a long term lifestyle plan.
It is important for the patient to have al the information available so that a common sense of purpose between the health care professionals and the patient can develop. This takes time and some patients may decide to reject advice.
Professionals need to maintain an open approach and emphasise that help is available when required.
Weight reduction is often difficult. A combined program of healthy eating, physical activity and education directed at behavioural changes is often successful. Carer and peer encouragement helps these behavioural changes.
Health care professionals need to be sensitive to patient views concerning diabetes and be ready to counsel. The normal stresses of daily living can affect diabetes control. Seek opportunities to help patients regain control, to improve self esteem and to understand and control their condition.
There is a range of approved educational materials produced by State and Territory Diabetes Organisations which can be recommended to the newly diagnosed person with diabetes. Education is ongoing and needs to continue for the rest of the person's life. Diabetes knowledge, especially self care skills (blood glucose monitoring, foot care, insulin administration) need to be assessed regularly (eg: as part of the complication screen at the twelve monthly review).
The team approach 21 4 Initial management Targets for glycaemic control in type 2 diabetes
Pre prandial blood
Post prandial blood
* NHMRC National Evidence Based Guidelines for Blood Glucose Control in Type 2 Diabetes, 2009The aim of treatment of type 2 diabetes is normal blood glucose levels (normoglycaemia). However, especially in the elderly, biochemical ideals should be tempered by common sense and the need to remove symptoms and maintain or improve quality of life. It is important to be clear about the aims of treatment. Over-zealous management can result in severe hypoglycaemia and may be associated with increased mortality. While there has been some discussion raised by recent trials about ideal targets, the targets as listed above are currently accepted. Patient blood glucose monitoring enables appropriate lifestyle and medication adjustment. Long term glycaemic control is monitored by measuring glycated haemoglobin (measured as HbA1c). The United Kingdom Prospective Diabetes Study (UKPDS) showed reduced incidence and progression of diabetes related complications in subjects with a low HbAlc. The IDF suggests that an HbAlc >7% should prompt more active hypoglycaemic treatment. The general HbA1c target in people with type 2 diabetes is ≤7%. An HbA1c target >7% may be appropriate in people with type 2 diabetes who have a history of severe hypoglycaemia, a limited life expectancy, co-morbidities or who are elderly. The Australian Diabetes Society Position Statement discusses individualisation of HbA1c targets for adults with diabetes mellitus (www.diabetessociety.com.au/position-statements.asp).
Working toward the target level is important but any significant reduction in HbA1c will improve patient outcomes. 4.1 Nutrition management involves controlling weight and the introduction
of a healthy eating plan.
Healthy eating is a critical component in the management of type 1 and type 2 diabetes. In over 50% of people presenting with type 2 diabetes restriction of energy intake, increased activity and weight reduction will initially normalise blood glucose levels. Medication is likely to be needed later.
Maintaining cooperation during weight reduction can be a major problem. A consistent coordinated approach by the general practitioner, dietitian and diabetes educator helps the patient maintain the effort.
22 Diabetes Management in General Practice There is evidence that Aboriginal and Torres Strait Islander communities in remote regions face significant access barriers to nutritious and affordable food. Nutritious food tends to cost more in rural and remote areas; cost may be an issue in low socio-economic groups. Food choices can be significantly altered when people have access to appropriate foods and education about nutrition. Nutritional guidelines
While an appreciation of the dietary management of diabetes by the general
practitioner or physician is important, detailed instructions need to be given by a dietitian. To find a qualified dietitian in your area, contact the Dietitians Association on 1800 812 942 or refer to your usual dietitian. Constant reinforcement of dietary advice usually results in enhanced cooperation and better control.
Healthy eating, body weight and regular physical activity are important objectives in people with diabetes. The following criteria of ‘overweight' apply to those of European descent. Different criteria may apply to other groups:Body Mass Index BMI (kg/m2) = Weight (Kilograms) Height squared (Metres2) The healthy BMI is 18.5 to 24.9, overweight 25 to 29.9, obese ≥30. As a rough guide the patient's healthy weight (kg) is approximately: Height (cm) – 100Alternatively waist circumference (cm) can be used. Weight for height chart for men and women from 18 years onward
HeiGHT – WiTHOUT sHOes Initial management 23 There is some evidence that rates of obesity in the Aboriginal and Torres Strait Islander population are higher than in the general Australian population. The diet for a person with diabetes is qualitatively no different from the Australian Dietary Guidelines recommended for al people (whether they have diabetes, hypertension, dyslipidaemia or not). The key issue of weight control is learning to eat a range of foods in amounts appropriate for energy requirements.
In people with type 2 diabetes increased activity and elimination of concentrated sources of energy with substitution with high fibre, carbohydrate foods will often bring the condition under control. Unless the patient is very symptomatic, a trial of at least 6 to 8 weeks of lifestyle modification is wise before oral hypoglycaemic agents are considered.
Loss of body weight will often result in near normal glycaemic, blood pressure and
lipid profiles. Often an ideal body weight is not achievable and setting this as a goal discourages patients to attempt any dietary change. Many studies suggest that a weight loss of 5 to 20% will improve glycaemic control. Therefore it is important to encourage any degree of weight loss. A medium term goal for overweight patients is 5–10% body weight loss.
Sources of hidden energy need to be identified and minimised: for example alcohol, cakes and sweet beverages. A reduction in total energy intake of 2,000 kilojoules (475 calories) per day should result in a weight loss of 0.5 kg a week.
Carbohydrate foods which are rich in fibre and have a low energy density are the
basis of the eating plan and it is recommended that they contribute up to 50% of the total energy intake. Meals containing carbohydrate are spread evenly through the day. Both the quantity of carbohydrate and the quality of carbohydrate will affect blood glucose levels. The amount of carbohydrate has a larger effect on glycaemia than the quality. The quality of carbohydrate is reflected by its glycemic index (GI) which indicates the post prandial glycaemic response to a particular carbohydrate food. This wil have a lesser but additional effect on blood glucose levels. The GI classifies carbohydrates as slow acting (low), moderate (medium) and quickly absorbed (high). Some foods have been GI tested in an accredited laboratory and the GI Symbol Program (sponsored by Diabetes Australia, Sydney University and the Juvenile Diabetes Research Foundation) indicates the GI of the food on their labels.
The glycemic load (GL) refers to both the quantity and the quality of carbohydrate. GL is the GI multiplied by the carbohydrate grams divided by 100. A lower GL (less than 80 GL per day) is desirable for people with diabetes. In practice it is 24 Diabetes Management in General Practice recommended that people with diabetes have one high fibre, low GI carbohydrate food at each meal. This would include wholegrain breads, rolled oats, low fat, low sugar breakfast cereals, pasta, beans, lentils and temperate fruits. Other carbohydrate foods can be included but in lesser amounts. These include rice, potato and tropical fruit.
Sugar does not need to be eliminated. Including a smal amount of sugar as part of a mixed meal or food, eg: breakfast cereal, does not adversely affect the blood glucose level. Allowing small amounts of sugar as part of a high fibre, low fat meal plan increases the choice of foods available and may aid adherence.
Low carbohydrate, high protein diets may predispose the person to hypoglycaemia if they are taking a sulphonylurea, repaglinide or insulin. Those adopting these diets should be made aware of the risk and the appropriate precautions.
It is recommended that fat contribute to less than 30% of total energy intake.
This has a beneficial effect on serum lipids and helps with weight reduction. Saturated fats in the diet will have an adverse effect on general lipid profiles.
The most common sources of oils and fats are:• Additives in cooking • Dairy products • Snack and takeaway foods.
Fried foods need to be avoided (even with polyunsaturated or monounsaturated oils).
Monounsaturated fats (Ω–9 fatty acids) as in olive oil or canola have a LDL-C lowering effect. Likewise seed sourced polyunsaturated oils (Ω–6 polyunsaturated) lower LDL-C. Fish oils (Ω–3 polyunsaturated oils) in doses of 5 g/day lower triglyceride levels. They also inhibit platelet aggregation and may protect against thrombosis in diseased blood vessels.
The main thrust of management is to lower total fat intake and to find
substitutes for saturated fats.
Low fat milk could be used as a substitute for whole milk and some ‘light' margarines have 40% of the fat content of standard margarines. Alternative spreads are reduced fat cottage cheese or ricotta cheese. Some margarines contain plant sterols that reduce cholesterol absorption and cholesterol levels.
There is considerable variation in the fat content of meats, depending on the source and cut. It is best to ask the butcher what is ‘lean' and what is not, especially since the ‘new cuts' are much lower in fat.
It is recommended that protein contribute 10–20% of total energy. The average
Australian diet achieves this without difficulty. Selection of type of protein depends Initial management 25 on patient preferences taking into consideration the fat content of each source. Vegetable sources of proteins such as beans and pulses are very low in fat.
As many people with type 2 diabetes are overweight or obese, alcohol should
be minimised. Australian guidelines at the time of publication recommend ≤2 standard drinks (20 g) per day for men and women. Low alcohol beers are a better choice than ordinary or diet beers.
Although Aboriginal and Torres Strait Islander people are less likely than non-Indigenous people to drink alcohol, those who do are more likely to drink at hazardous levels. Hazardous drinking is more prevalent among Indigenous Australian males and females aged 35–44 years than the general population. Added salt in cooking and in foods needs to be minimised. Recommend the use of ‘low salt' or ‘no added salt' products.
Although small amounts of sugar can be included, alternative sweeteners may still have a role in management. Suitable sweeteners include aspartame, sucralose, acesulphame K, alitame, saccharin and cyclamates. It should be noted that all sweeteners are deemed by the Food Standards Australia and New Zealand as suitable and safe for use in pregnancy, although some are known to cross the placenta. If concerned, pregnant women should speak to their health professional. The inclusion of sugar alcohols, eg: sorbitol, is not recommended as these offer no advantage over sucrose in improving metabolic control, increasing cooperation or in managing weight loss.
Physical activity • Regular physical activity improves metabolic control and reduces
other cardiovascular risks.
• Patients on insulin, sulphonylureas or repaglinide may need to take
special precautions to prevent hypoglycaemia.
• Appropriate care of feet during physical activity is important.
Increasing physical activity improves metabolic control in people with diabetes. Low level aerobic exercise (eg: brisk walking for half an hour per day) and physical resistance training have the following benefits:• Improved glucose tolerance as insulin sensitivity increases • Increased energy expenditure resulting in weight loss 26 Diabetes Management in General Practice • Increased feeling of well being • Increased work capacity • Improved blood pressure and lipid profiles.
Aerobic training which ‘makes you puff ' and brings the heart rate up to 60–70% of maximum (220 – age [years] beats per minute) for a minimum of 30 minutes 3 or 4 times per week, establishes and maintains fitness and aerobic capacity. Active Australia recommends >150 minutes per week of moderate intensity physical activity (eg: walking).
When prescribing a physical activity program a careful history should be taken. Special attention needs to be paid to exertion-induced symptoms such as chest or abdominal discomfort or syncope. People with type 2 diabetes frequently have silent macrovascular disease. Consider second yearly ECG if a patient is over 50 years old and has at least one vascular risk factor. Screening with a stress ECG is not indicated in asymptomatic individuals, but specific symptoms need to be actively investigated.
Isometric exercises such as heavy weight lifting (high load, low repetition) may increase blood pressure, increasing the risk of vitreous haemorrhage and sudden cardiac events. However, resistance programs using moderate weights and high repetition can be part of an exercise program for those with diabetes and have been shown to improve glycaemic control.
People requiring insulin may need to increase their carbohydrate intake and/ or decrease their insulin before exercise. They need to also carry some refined carbohydrate with them. Similarly people with type 2 diabetes taking sulphonylureas or repaglinide may need to take extra food and/or reduce their medication.
People requiring insulin need to be aware of potential delayed effects of physical activity on glucose levels, in particular delayed hypoglycaemia 6–12 hours after cessation of the activity. People with diabetes need to be advised to cease their activity if they develop cardiovascular symptoms or just feel unwell. However, patients with leg or buttock claudication need to be encouraged to continue physical activity with intermittent rests when leg or buttock pain occurs since this will gradually increase their capacity to exercise.
The importance of appropriate foot care and comfortable, well-fitting footwear during physical activity needs to be stressed, especially if there is neuropathy, vascular disease, abnormal foot structure or previous foot ulcer(s).
Lower levels of physical activity have been reported for Aboriginal and Torres Strait Islander people and people living in rural and remote areas. There is poor access to facilities for physical activity in many Aboriginal communities.
Initial management 27 5 Health care for diabetes • Self-monitoring is recommended for those on agents that can
• Home blood glucose monitoring is the method of choice in
• The method and frequency of testing need to reflect
Blood glucose monitoring is recommended for those on agents that can cause hyperglycaemia (eg: sulphonylureas and insulin). A balance should be reached considering the patient's age, need for ideal control and ensuring long term cooperation. Despite some recent controversial studies, the current view is that blood glucose monitoring is recommended.
Initially close supervision is recommended. A suggested initial schedule of testing is 3 to 4 blood glucose tests daily (early morning, plus other tests before + after meals). Frequent consultation with health care professionals is important.
Self-monitoring needs to be individualised and assist people with diabetes to understand the impact of medication, food and physical activity on blood glucose control. Frequency of self-monitoring can be determined according to the individual's self management goals.
In elderly patients testing on 1 or 2 days per week, varying the time, may be adequate if diabetes control is good.
Monitoring in type 2 diabetes need not be as intensive as with type 1 diabetes except when the normal pattern is broken (eg: travelling, the festive season, intercurrent illness, changes to medication and diet). The ideal would be blood glucose estimation before + after meals. A reasonable approach in a patient with stable glycaemic control would include blood glucose estimation at different times of the day on 2–3 days each week.
Values before meals give information about baseline glycaemia which is affected by general factors such as weight, diet, activity and long acting medication. Values after meals give information about peak glycaemia which is affected by the baseline level, the food eaten and short acting medication.
People on either insulin or oral hypoglycaemic agents must be able to identify ‘hypos' and understand treatment. Blood glucose monitoring can be of help.
Targets for self-monitored blood glucose levels are 6–8 mmol/L fasting and pre prandial, and 6–10 mmol/L 2 hours post prandial (see page 22).
28 Diabetes Management in General Practice Many people learn to adjust their treatment schedule according to blood glucose levels and thus improve glycaemic control. People can measure their blood glucose using reagent strips that are read in the meter and/or visual y (for some strips). Meters today are quick, reliable and simple to use. Use of the meter should be demonstrated. People need to be competent in the technique of blood glucose monitoring before treatment decisions based on the readings are made. Al meters need regular quality control checks by the user. All self blood glucose measurement systems have quality control materials.
Medical monitoring Regular follow-up visits offer an opportunity for the general practitioner and patient to explore the patient's understanding, fears and concerns about diabetes. Some practices run diabetes clinics, often delivered by practice nurses. The use of practice protocols, checklists and algorithms that have been developed by the doctors and nurses in a practice ensures the practice nurse can undertake a large proportion of the routine care (under the clinical oversight of the doctor).
The following is a guide for the doctor's oversight of patients. A suggested checklist for nurse activity appears at the end of each section. Results of nurse consultation should be incorporated into the clinical record. As this checklist assumes the knowledge and clinical experience of a registered nurse, practices should use it according to the professional and clinical status of their nursing staff.
5.2.1 Quarterly review
• Discourage smoking • Review symptoms
• Check weight, BP
• Review self-monitoring
Once control is achieved the routine visit should review:
Review SNAP profiles (Smoking, Nutrition, Alcohol, Physical activity), patient's
record of home testing and quality control results, foot symptoms.
Check weight/waist, height (children and adolescents), blood pressure,
feet examination if new symptoms or at risk (eg: neuropathy ± peripheral vascular disease).
Measure glycated haemoglobin (HbA1c) at least six monthly.
Watch for intercurrent illnesses such as urinary tract infections, thyrotoxicosis etc
which may alter degree of control. Asymptomatic urinary infections are common in patients with diabetes, especially older women.
Health care for diabetes 29 188.8.131.52 Quarterly nursing review
How much exercise and how often Any problems with medication Height (children and adolescents) Feet examination without shoes, if new symptoms or at risk (eg: neuropathy ± peripheral vascular disease) Goals with patient to identify specific areas of focus for doctor consultation 5.2.2 Annual review
• Review goals of management • Check for diabetic complications
• Update immunisation schedule • Consider specialist referral
The yearly review is a time for more detailed assessment, updating the problem priority list and re-establishment of goals, and contractual arrangements for management. Eating plan, lifestyle, home monitoring and treatment need to be reviewed.
There needs to be a ful system review checking for vascular, renal, eye, nerve and podiatric problems. As there is an increasing trend towards involving specialist allied health professionals, the yearly visit is a good opportunity to coordinate follow-up.
Full physical assessment:
• Cardiovascular system
• Peripheral nervous system Immunisations:
• Pneumococcal Non-Aboriginal and Torres Strait Islanders:
<65 – single dose and revaccinate age 65 or after 10 years whichever later >65 – single dose and revaccinate 5 years later Aboriginal and Torres Strait Islanders:
<50 – single dose and revaccinate age 50 or after 10 years whichever later >50 – single dose and revaccinate 5 years later Booster at age 50 (unless booster has been given within 30 Diabetes Management in General Practice Investigations: (annually if below target, more frequently if being actively treated)
Lipids – triglyceride; HDL-C, LDL-C and total cholesterol
Renal – microalbuminuria and plasma creatinine (eGFR)
Ophthalmologist/optometrist – second yearly with no retinopathy, more
frequently if abnormal.
Diabetes educator, dietitian, podiatrist – if patient has or has developed a problem requiring review.
Pharmacist – for a Home Medicines Review if the patient is likely to have problems with medication (eg: taking more than 5 types).
Oral health professional – especially if peridontal disease is present.
184.108.40.206 Annual nursing review
Nutrition (last contact with dietitian or diabetes educator) How much exercise and how often Any problems with medication Any changes in medication (by doctor/pharmacist or patient) Vision (when last checked) Any foot discomfort When was last podiatry and dental check Immunisations (include Flu and Pneumovax) Family history and update Height (children and adolescents) Feet examination: without shoes, pulses, monofilament check Blood glucose at examination Goals with patient to identify specific areas of focus for doctor consultation Last care plan to identify timely referrals Registration with NDSS/membership of State or Territory Diabetes Organisation Health care for diabetes 31 Records:
The use of a check list and a separate sheet in the patient's notes (preferably attached
to the front of the problem list) can be used to record the frequency and results of these assessments. Medical software incorporates acceptable forms of diabetes records. These accrue to support the annual cycle of care which can be used for the Medicare items (see page 34).
Diabetes is a complex disorder and requires a systematic approach to care. There is evidence that this approach in the general practice setting results in better outcomes.
A systematic approach to care is facilitated by the use of:
1. Disease register: This is a list of all patients in the practice with diabetes and
basic demographic data. The register can also include clinical information. This allows tracking of patients' clinical status and their need for ongoing care.
2. Recall system: This facilitates timely recall of patients when certain aspects of
their care require review eg: recall for annual review, ophthalmologist review, etc.
3. Flow charts: Included in the patients' notes these allow following of clinical
parameters and flag when interventions or investigations are necessary.
4. Review charts: Included in the patients' notes, these are checklists for annual
and three monthly reviews to facilitate thorough coverage of all issues at these The RACGP and General Practice networks have resources to assist practices in establishing such systematic approaches to the care of their patients with diabetes.
5.3.1 How Medicare supports the process
The Australian Government supports high quality care through a series of
non-fee-for-service payments to general practitioners and general practices. These include the Enhanced Primary Care Program and the Practice Incentive
Program. The Practice Incentive Program is only available to general practices
either accredited or working towards accreditation by the RACGP.
As a result of these programs, services performed by a number of allied health professionals (including diabetes educators, Aboriginal health workers, dietitians, psychologists, podiatrists, exercise physiologists and dentists) may attract a rebate 32 Diabetes Management in General Practice when a patient sees them within the Enhanced Primary Care Program. There are also Medicare items for group intervention services provided by eligible dietitians, diabetes educators and exercise physiologists within this system.
Al Australians are eligible to have a Medicare funded eye check by an optometrist, with or without a GP referral, once every 2 years. Many optometrists bulk bill this check. People with diabetes can use this for diabetes eye checks.
The National Integrated Diabetes Program was established to improve the
prevention, early diagnosis and management of people with diabetes. The initiative includes a general practice incentive, a general practice network incentive and a community awareness campaign. The incentive program requires practices to register and create a patient register and recall/reminder system, with additional incentives for completing an annual cycle of care and further incentive for reaching target levels of care for people with diabetes.
Some people with diabetes wil require complex medication schedules and a Home Medicines Review may be useful (Medicare item 900). This involves a
pharmacist assessing people who may have problems with their medications, and recommending changes to improve effectiveness, safety and adherence.
Some patients find diabetes a significant burden. They may benefit from the support of a psychologist, social worker or counsel or. Access to these practitioners is available under the Better Access to Psychiatrists, Psychologists
and General Practitioners through the Medicare Benefits Scheme Initiative.
Practice nurses do not have the ability to charge Medicare rebatable items
for care related to diabetes. General practitioners who work in urban areas
of workforce need can apply for grants to employ nurses (under the program
Strengthening Medicare) as can rural practitioners through the ongoing
rural nurse program grants.
The Medicare Benefits Schedule item number 715 provides for a health check for Aboriginal and Torres Strait Islander people who have not had the check in the previous 18 months. There are time based health check items for all Aboriginal people (items 701,703,705,707: see www.health.gov.au/mbsonline)Preparation of a GP Management Plan (item 721) and coordinating the development of Team Care Arrangements (item 723) are also appropriate supports for comprehensive management of diabetes for Aboriginal and Torres Strait Islander people.
Health care for diabetes 33 5.3.2 Required annual cycle of care
12 monthly review Issues under control? Consider GPMP and TCA Continue management Issues under control? Issues under control? No 1 Annual review:
Refer 5.2.2, pages 30 and 31 2 GPMP/TCA:
Refer 5.3.3 & 5.3.4, pages 35 and 36 3 GPMP/TCA review: Refer 5.3.3 & 5.3.4, pages 35 and 36
4 3 monthly review: Refer 5.2.1, pages 29 and 30
Item numbers which can be used are:
Vocationally registered GPs
Non-vocationally registered GPs
Long consultation Prolonged consultation 34 Diabetes Management in General Practice In addition, general practitioners working in accredited practices who have applied for PIP (Practice Incentive Program) will attract SIP (Service Incentive
Program) payment for themselves and PIP payments for their practices
The SIP cycle requires:
Ht/wt/waist (BMI) Glycaemic control (HbA1c) at least every 2 years review once per year Healthy eating plan review once per year Physical activity review once per year Self care education review once per year review once per year These are the levels of care for the SIP cycle payment and obviously more care will be required for those with complications and co-risk factors. 5.3.3 General Practice Management Plans (GPMP)
These are documented plans developed by the general practitioner and patient
together, that incorporate the patient's needs, goals, how this is to be achieved and reference to any other resources used. Templates for use are available via medical software and General Practice networks.
Item numbers which can be used are:
Initial preparation: Payable 1–2 yearly depending on need for revision Payable every 3–6 months, but not within 3 months of 721 (* item 732 replaces 725)Involvement in GPMP developed by another provider Involvement in a care plan developed by an aged care facility 731 Health care for diabetes 35 5.3.4 Team Care Arrangements (TCA)
These are an expansion of the GPMP which detail the allied health workers who
implement any part of the GPMP.
Item numbers which can be used are:
Initial preparation: Payable 1–2 yearly depending on need for revisionReview of plan: Payable every 3–6 months, but not within 3 months of 723(* item 732 replaces 727 and is the same item number as the review for 721) Ongoing monitoring and support provided by a practice nurse on behalf of a GP for up to 5 visits, for a person with a chronic condition who has an operational GPMP Access to al ied health and dental EPC items requires a GPMP and TCA, or item 731 if in an aged care facility. GPMP and TCA can be developed and claimed simultaneously.
Please note: Under the changes to Medicare Item descriptors from 1 May 2010, there is no change to the items applicable to Diabetes Cycles of Care.
36 Diabetes Management in General Practice Multiple interventions and medications are needed to control the multiple risk factors associated with type 2 diabetes (hyperglycaemia, hypertension, dyslipidaemia and increased thrombogenesis).
oral hypoglycaemic agents • Medication will not substitute for healthy eating and activity.
• Metformin is the medication of choice in the overweight person
with type 2 diabetes.
• Weight gain can be a problem with sulphonylureas and
thiazolidinediones and hypoglycaemia can be a problem with
sulphonylureas. Acarbose may cause flatulence and diarrhoea.
Fluid retention can occur during glitazone therapy and caution is
necessary in cardiac failure.
• Allergy to a specific medication is a contraindication to its use.
If a trial of healthy lifestyle for 6 weeks or more is unsuccessful in controlling blood glucose in a person with type 2 diabetes, oral hypoglycaemic agents can be used (see chart pages 41–42). If the patient is symptomatic at initial diagnosis or the blood glucose level is very high (>20 mmol/L), medication can be used early to decrease glucose levels and relieve symptoms.
Metformin is the medication of first choice in people with diabetes (see chart pages 41–42). Metformin reduces hepatic glucose output and insulin resistance. Metformin has been shown to significantly reduce the risk of diabetes-related morbidity and mortality in overweight patients. Renal impairment is the only absolute contraindication to metformin (ie: a raised serum creatinine which usually reflects significantly impaired renal function). Metformin is contraindicated in people with a GFR <30 ml/min and should be used with caution in people with a GFR of 30–45 ml/ min. Metformin should be used with caution in people with hepatic or cardiac disease and those with a heavy alcohol intake.
Sulphonylureas increase insulin secretion and can be used after a trial of healthy lifestyle and metformin.
Acarbose is useful when blood glucose values remain high after meals despite dietary modification. Acarbose inhibits the digestion of carbohydrate and thus slows the rate of glucose delivery into the circulation. Acarbose needs to be taken at the time of starting the meal and introduced gradually to avoid flatulence and abdominal discomfort. If hypoglycaemia occurs (because of concurrent sulphonylurea or insulin treatment) glucose rather than other carbohydrates is required. Care is necessary in those with renal impairment or gastrointestinal disease and liver enzymes need to be monitored.
Repaglinide causes a rapid, transient increase in pancreatic insulin secretion. Repaglinide can be used as mono therapy or with metformin to control post prandial hyperglycaemia. It should not be used in combination with sulphonylureas.
The glitazones (pioglitazone and rosiglitazone) are effective in lowering blood glucose by reducing insulin resistance.
Both glitazones can be used as dual therapy with metformin or sulphonylureas.
Pioglitazone can also be used in triple therapy with metformin and a sulphonylurea or in combination with insulin. Contraindications include moderate to severe cardiac failure.
Rosiglitazone is not indicated in triple therapy with metformin and a sulphonylurea or in combination with insulin. Contraindications include mild, moderate to severe, or any history of cardiac failure.
Rosiglitazone is not recommended in patients with known ischaemic heart disease,
particularly in those taking nitrates. Refer to Product Information for more details. Care is necessary in those with any degree of cardiac failure or liver dysfunction.
Two classes of medications now target the glucagon-like peptide (GLP-1) actions. GLP-1 enhances insulin secretion and inhibits glucagon secretion in a glucose dependent manner. GLP-1 increases satiety and decreases gastro-emptying. Both fasting and post prandial glucose are reduced.
Two different pharmacological strategies target the GLP-1 axis.
1. DPP-4 inhibitors. Three drugs inhibit DPP-4 and increase and prolong the
action of native GLP-1 (saxagliptin, Onglyza; sitagliptin, Januvia and vildagliptin, Galvus). They are all subsidised by the PBS. They mainly improve post-prandial BGLs, are weight neutral and do not cause hypoglycaemia, unless used in combination with sulphonylureas.
2. GLP-1 agonists. Naturally occurring or synthetic analogues of GLP-1 are
currently under development. One agonist (exenatide, Byetta) is available for use in patients with type 2 diabetes. It can decrease fasting and post-prandial BGLs as well as causing weight loss. Patients initiated on exenatide should commence therapy with the 5 µg dose administered twice daily before the morning and evening meal. After one month, the dose is up titrated to the maintenance dose of 10 µg bd. Patients should be warned that nausea and anorexia can occur in the first few weeks but this is usually mild and doesn't persist. However, 5–10% of patients may have to discontinue this therapy because of side effects.
With sulphonylureas, special care needs to be taken, especial y in the elderly, not to precipitate hypoglycaemia. When used as mono therapy, metformin, acarbose, glitazones, GLP-1 mimetics and DPP-4 inhibitors wil not cause hypoglycaemia. All the sulphonylureas can cause hypoglycaemia. People taking sulphonylureas, repaglinide or insulin may need to notify motor vehicle licensing authorities and their insurance company as these medications can affect driving performance (see page 75).
38 Diabetes Management in General Practice Start with a smal dose and increase weekly or fortnightly until control occurs. If control is not occurring check the patient's understanding of management and monitoring skil s and if these are satisfactory, look for other exacerbating factors such as occult urinary tract infection or medications which may interfere with control.
If a patient continues to lose weight while on oral hypoglycaemic agents the dose may be reduced and sometimes stopped.
Most people with diabetes will require increasing doses and additional medications as their diabetes progresses. Insulin therapy may also be required.
Main side effects of oral hypoglycaemic agents
• Anorexia, nausea, vomiting
• Flatulence and abdominal bloating
• Diarrhoea, abdominal cramps, flatulence • Non response to carbohydrates other
• Lactic acidosis (if renal, liver
than glucose if hypoglycaemic or cardiovascular disease exist) • (Rare) liver abnormalities
• Weight gain
Exenatide: • Symptomatic hypoglycaemia
• Nausea and vomiting
• Anorexia, nausea, diarrhoea,
• Injection site reactions
• Possible pancreatitis
• Occasionally blood dyscrasias
• Upper respiratory infection
• Increased subcutaneous fat and/or fluid
• Urinary tract infection
• Decreased haemoglobin levels
• Increased risk of peripheral fractures
Sitagliptin: • Possible increased risk of myocardial
• Increased LDL-C (rosiglitazone)
• Upper respiratory tract symptoms
Vildagliptin: • Symptomatic hypoglycaemia
• Nausea, diarrhoea, constipation
• Skin rashes, abnormal LFT
• (Rare) hepatitis and/or jaundice
Effects of non-diabetes medications
Beware of interaction with other medications which increase or decrease blood glucose action:
Reduce blood glucose
Increase blood glucose
Adrenergic compounds Monoamine oxidase inhibitors Thiazide diuretics (high dose) Salicylates – in high doses* * Low dose aspirin (100–300 mg/d) does not cause problems. † Increases effect of repaglinide. Socioeconomic disadvantage, increased co-morbidity and higher family burden of chronic disease can create a significant barrier to affordability of medications for the Aboriginal and Torres Strait Islander population. Evidence also suggests that some Aboriginal people are uncomfortable seeking medicines advice, and the consumer medicine information provided is often difficult to understand, culturally inappropriate and unlikely to be utilised. Medication sharing is common in some communities. Treatment algorithm: PBS approved medications for type 2 diabetes
LIFesTYLe MODIFICATION • Diet modification• Weight control• Physical activity • The algorithm is based on that published by the NHMRC. • The algorithm includes only therapeutic agents available through the PBS. • If HbA1c >7% consider intensifying treatment provided hypoglycaemia is not a problem.
# Saxagliptin, sitagliptin and vildagliptin are PBS subsidised only for dual therapy with metformin or sulphonylurea where combination therapy metformin and sulphonylurea is contraindicated or not tolerated. Exenatide is approved for use as dual or triple therapy with oral agents. * Rosiglitazone is not authorised for triple therapy or for use with insulin but is approved only as dual therapy with metformin or sulphonylurea where combination metformin and sulphonylurea is contraindicated or not tolerated.
† Insulin is frequently required for glycaemic control in people with type 2 diabetes and can be initiated as basal therapy or as premixed insulins, usual y in combination with oral antidiabetic medications. 40 Diabetes Management in General Practice Oral hypoglycaemic agents available
Approx Frequency Administration duration (time/day) (time/day) Chemical name: Acarbose (a)Glucobay Chemical name: Glibenclamide (b)Daonil Chemical name: Gliclazide (b)Diamicron 40–320 mg 18–24 h 1–2 Genrx gliclazide Chemical name: Gliclazide ER* (b)Diamicron MR Chemical name: Glimepiride (b)Amaryl AylideDiaprideDimirel Glimepiride SandozChemical name: Glipizide (b)Melizide MinidiabChemical name: Metformin (c,e)Diabex 0.5/0.85 g/1.0 g 0.5–3.0 g Metformin (Genepharm) Metformin (Generic Health) 0.5/0.85 g/1.0 gMetformin (Ranbaxy) Metformin (Sandoz) Note: Oral agents need to be used with special care in the elderly. Continued over (a) Care renal, gastrointestinal disease (c) Metformin (e) Care renal, liver and cardiovascular disease (b) Sulphonylurea * ER = Extended Release Medication 41 Approx Frequency Administration duration (time/day) (time/day) Chemical name: Metformin ER* (c)Diabex XR Chemical name: Metformin/glibenclamide (b,c,e)Glucovance Chemical name: Metformin/ rosiglitazone (c,d,e,f)Avandamet 1000/2 mg 1000/4 mg Chemical name: Metformin/sitagliptin (c, e, f)Janumet Chemical name: Pioglitazone (d, e, f,)Actos Chemical name: Repaglinide (g)NovoNorm Chemical name: Rosiglitazone (d,e,f)Avandia Without regard to meals Chemical name: Saxagliptin (f,h)Onglyza Without regard to meals Chemical name: Sitagliptin (f,h)Januvia Without regard to meals Chemical name: Vildagliptin (f,h)Galvus Without regard to meals Chemical name: ExenatideByetta Twice daily non-insulin hypoglycaemic agent. Inject 5 µg bd subcutane- ously one hour before two main meals and at least 6 hours apart. After one month increase to 10 µg bd.
(a) Care renal, gastrointestinal disease (d) Thiazolidenedione (g) Private script (b) Sulphonylurea (e) Care renal, liver and cardiovascular disease (h) Care renal insufficiency (c) Metformin (f) Streamlined authority required * ER = Extended Release 42 Diabetes Management in General Practice Insulin treatment Starting insulin in type 2 diabetes
Insulin may be required if adequate control has not occurred on maximum doses
of oral hypoglycaemic agents. However, ensure that exercise and dietary management are satisfactory and exacerbating factors eg: intercurrent infection, problems with medication (see page 69) have been excluded.
Insulin may be needed early in the condition when treatment is being started (the so-called ‘primary' failure of oral hypoglycaemic agents that suggests the patient actually has type 1 diabetes) or when the patient has later become refractory to oral hypoglycaemic agents (so-called ‘secondary' failure consistent with the usual progression of type 2 diabetes).
If the patient is symptomatic then insulin is required. If there are no symptoms but fasting blood glucose levels are consistently >7.0 mmol/L, the decision is more difficult.
When deciding glycaemic targets and considering insulin treatment, take into account: life expectancy, existing physical and psychosocial problems and potential problems with insulin.
The selection of treatment goals, treatment schedules and monitoring schedules needs to be a decision arrived at after discussion with the patient and may be the stimulus for a General Practice Management Plan (see page 35).
Initiation of treatment with insulin is regarded as a major step by most patients. They require encouragement and psychological support.
At this stage the help of a physician with a special interest in diabetes may • Insulin is not a substitute for healthy eating, activity and weight
control in type 2 diabetes.
• Inappropriate use of insulin produces weight gain and continuing
Step guide to insulin treatment in type 2 diabetes
People with type 2 diabetes requiring insulin can often be managed with a single
daily dose of intermediate or long acting insulin added to their oral hypoglycaemic schedule. Quick acting insulin is not necessarily needed. A recommended starting schedule is a single dose of basal insulin (eg: 10 units at bedtime or breakfast). The basal insulin can be isophane or glargine. Glargine may cause less hypoglycaemia than isophane.
In the long term metformin can be continued or added to reduce insulin resistance (and dose) and to help reduce weight gain.
Check that diet, activity and oral medication are appropriate and that complicating
medical conditions are not present.
Step 2 – Decide the time and type of insulin
Twice daily isophane/once daily glargine Step 3 – Dosage
Decide the target (see page 22)
Decide the dose: ‘start low and go slow' (eg: 10 units basal)
morning or evening Less may be required in elderly, active, thin patients and more in the overweight and underactive.
Step 4 – Adjust doses
Change doses in increments of 10–20% (eg: 2–4 units) at intervals of 2–4 days.
Mixed insulins may be needed.
Pre mixed insulin
Alternatively, pre mixed insulin (human or analogue) can be used with a single
dose before the largest meal (often the evening meal) or twice daily doses (before breakfast and the evening meal). As with basal insulin, the dose should ‘start low and go slow' (eg: starting dose 10 units with changes in increments of 10–20% at intervals of 2–4 days).
44 Diabetes Management in General Practice Choosing the insulin
Short acting insulin
The speed of onset and length of action is shortest for the insulin analogues,
followed by human neutral insulin and then by bovine neutral insulin.
The isophane/NPH preparations can be used in injectors or syringes and do not
affect the kinetics of added neutral insulin. The isophane/NPH preparations have replaced the insulin zinc suspension (lente type) preparations.
Long acting insulin
The bovine isophane preparation is longer acting than the human isophane
preparations which may not provide 24-hour cover. The absorption profile of new analogue basal insulin preparations (insulin detemir, insulin glargine) is longer, flatter and more reproducible than previous long-acting preparations. At the time of writing, the only long acting analogue insulin subsidised by the PBS for insulin therapy in type 2 diabetes is insulin glargine (Lantus).
Pre mixed insulin
Although the fixed proportions of intermediate and quick acting insulin
(eg: 30% neutral, 70% intermediate) may not be ideal for glycaemic control, these preparations are very convenient for patients to use.
Diet, exercise and insulin
The depot of insulin will work whether the person is eating or undertaking physical
activity. Both exercise and eating should be regular to increase the predictability in blood glucose levels.
Sites for insulin injections
• Abdominal wall: Generally fastest and the most uniform rate of absorption.
• Legs: Slowest absorption (unless exercising). Acceptable site.
• Arms: Not recommended.
Injections should be subcutaneous.
Insulin injectors are like large fountain pens with a cartridge of insulin inserted like an
ink cartridge. They make injections much simpler since drawing up is unnecessary. Older people may find the Innolet injector easier to use because it is larger and markings are more visible.
With insulin injectors, multiple daily injection schedules become much easier and people can be more flexible in their self management.
Free insulin syringes and subsidised test strips for self-monitoring are available
through State and Territory Diabetes Organisations to members and non-members alike. To be eligible, patients must register with the National Diabetes Services Scheme (NDSS) by contacting their State or Territory Diabetes Organisation on 1300 136 588 (see page 82).
Patients often reuse syringes but in situations where injections are given by visiting nursing staff, single use only is recommended. In children it may be desirable to reduce the number of uses of a single use syringe to keep the needle sharp.
Insulin pumps are used by some people with type 2 diabetes (refer 6.6 New
technology page 49). The pump is attached to the person's clothing and infuses ultra short acting insulin at variable rates into the subcutaneous tissues through an infusion set. Insulin pumps can be programmed to provide variable basal insulin infusion rates throughout the day and can also provide preprandial doses of bolus insulin.
People can dispose of sharps (blood-letting lancets, syringes etc) in an approved
sharps disposal container. Arrangements for the col ection of sharps vary in different States and Territories (eg: local council, hospital). People can contact their State or Territory Diabetes Organisation for advice.
Follow upThe insulin schedule and dosing should be reviewed at each consultation to review diabetes. The insulin dosage may need to be reduced if the person adopts a healthier lifestyle and/or loses weight.
46 Diabetes Management in General Practice Insulins available Brand Name
ULTRA SHORT ACTING (peak at 1hr, last 3.5–4.5 hrs)
Insulin glulisine SHORT ACTING (peak at 2–5 hrs, last 6–8 hrs)
INTERMEDIATE ACTING (12–24 hrs)
Insulin detemir (up to 24 hrs)
Insulin glargine (24 hrs)
PRE MIXED INSULINS
Lispro protamine 75% Lispro 50%
Lispro protamine 50% Insulin aspart 30%
Insulin aspart protamine 70% Neutral 30%
The pharmacokinetics of the different insulins are patient dependent. Please review product information for each product before prescribing. An empirical approach to dosage together with a ‘go slow' policy will result in the smoothest fine tuning of management. Some of these insulins are available as injection devices, pen injectors, disposable insulin pens, cartridges and vials.
+ Very quick acting. Should be given immediately before eating. Problems with medication Insulin and sulphonylureas can cause symptomatic hypoglycaemia and
weight gain. Patients and their families need to be aware of the risk
and be able to manage hypoglycaemia.
Hypoglycaemia may arise due to excessive insulin or sulphonylurea dose, deficient
carbohydrate intake or unaccustomed exercise. The cause needs to be identified and the episode dealt with by reinforcing education, counselling the patient and perhaps changing treatment.
Those who are taking insulin secretagogues or insulin, striving for ideal control, the elderly, those on beta–blockers and those who live alone or have a high alcohol intake are at special risk.
• If the patient is conscious, initial treatment should be with oral
glucose or sucrose.
• If the patient is unconscious give glucagon 1 mg subcutaneously,
intramuscularly or intravenously. (Glucagon is available through the
PBS as ‘Glucagen hypo kit', suggest one at work and one at home).
• Carers and work colleagues of the at risk person with diabetes
should be familiar with the identification of hypoglycaemia and its
treatment including subcutaneous glucagon administration.
• If the doctor is available and glucagon fails to restore
consciousness, administration of intravenous 50% glucose 20–30
ml should follow the glucagon.
• It is important to follow resuscitation with ongoing monitoring and
The general practitioner is in a unique situation to be able to identify possible
factors which contribute to poor control. The general practitioner can explore the patient's understanding of diet, self-monitoring, treatment, as well as anxieties about the condition. The general practitioner can also appreciate the dynamics within the family and socio-economic stresses experienced by the patient. Factors worth considering in poor control are: • Inappropriate food intake • Inappropriate insulin or oral hypoglycaemic usage • Irregular metabolic demand, eg: exercise, shift work • Intercurrent infection (especially urinary tract infection) • Incorrect administration of medication/insulin • Psychological stress.
48 Diabetes Management in General Practice Two new technologies which are used in the management of type 1 diabetes are now being used in type 2 diabetes: insulin pumps and continuous glucose monitoring systems (CGMS). Generally, these new technologies are prescribed and monitored by specialist colleagues.
Insulin pumps infuse continuous (basal) subcutaneous insulin and extra boluses as needed (eg: at meals or to correct high blood glucose values). Pumps offer the flexibility of having different basal insulin doses at different times of the day and of being able to quickly change insulin delivery. Subsidised insulin pump consumables are available to Registrants of the National Diabetes Services Scheme who meet additional criteria.
CGMS sample subcutaneous glucose levels approximately every 8 minutes and can give continuous blood glucose levels over a 24 hour period for up to 6 consecutive days. They can be useful in determining the appropriate doses and timing of subcutaneous insulin. They may also have an important role for patients where they are in a situation where hypoglycaemia must be avoided.
These two technologies can be combined and give information about blood glucose and the capacity to flexibly deliver insulin. As yet they do not automatically adjust insulin delivery according to the measured glucose values.
Surgical procedures Management aims at reasonable glycaemic control before, during and after surgery.
People with diabetes should be seen several weeks before surgery for assessment of diabetic control and anaesthetic suitability.
Minor or ‘day only' procedures usually involve fasting from midnight (if held in the morning) or a light breakfast and then fasting (if held in the afternoon). In either case oral hypoglycaemic agents should be withheld.
For colonoscopy preparation, Colonlytely rather than Fleet should be used in patients with renal impairment who may become severely hyperphosphataemic with Fleet.
Appropriate written instructions should be given to the patient beforehand.
Major surgery causes considerable stress to the patient. Metformin should be
ceased before major surgery. Pre operative care is the same as for minor surgery,
but blood glucose levels should be monitored intra operatively (if a prolonged procedure) and post operatively for several days. Insulin is often required post operatively for people with diabetes.
Patients with diabetes treated with insulin will usually require peri operative insulin and glucose infusions and close blood glucose monitoring.
• Look for the underlying cause and treat.
• Increase self-monitoring.
• Ensure continuity of advice (especially after hours).
• Usually an increase in medication is needed.
In any chronic condition it is inevitable that additional episodes of sickness will occur from other causes. Sick day management needs to be part of normal patient education.
Patients need to have a plan for sick days negotiated in advance. This plan should include:• When to call the doctor• How often to measure blood glucose and urinary ketones• What medicines to take • How to eat.
It is important that telephone access to a resource person is available. Telephone advice may be sufficient when the patient is knowledgeable about diabetes but if any doubt exists, a formal consultation needs to be arranged. The patient should make contact if they have been unwell for a couple of days and not getting better, if they have moderate (or more) ketones in their urine, if the blood glucose is rising despite taking medication or if they are unsure of what to do for their care.
Intercurrent illnesses, infections (urinary tract infections, boils), trauma, acute myocardial infarction and stroke will worsen control. In addition the use of corticosteroids, beta agonists and diuretics may impair control.
The important aspect is to increase self-monitoring:• Blood glucose measurement 3–4 times/day• Checking blood or urine for ketones if blood glucose is over 15 mmol/L (in type 1 diabetes).
Patients should try to maintain their normal meal plans if possible. Fluid intake (eg: water) should be increased to prevent dehydration. Advise about alternative easy-to-digest foods like soups if the patient cannot tolerate a normal diet. Some non-diet soft drinks may provide essential carbohydrate in this situation.
50 Diabetes Management in General Practice Type 2 diabetes controlled with diet alone
Worsening control may require the addition of sulphonylurea or insulin temporarily.
These patients are generally not ketosis prone but increased blood glucose levels will impair the body's immune mechanisms and make recovery slower. In addition they may become dehydrated because of the osmotic diuresis.
Type 2 diabetes on oral hypoglycaemic agents
Worsening control may require the use of insulin temporarily. This may require
hospital admission. In patients with nausea, vomiting and/or diarrhoea, consider stopping metformin temporarily as metformin may aggravate these symptoms.
Type 1 diabetes and type 2 diabetes on insulin
Patients should increase their morning intermediate or long acting insulin dose
by 10–20% and depending on further blood glucose levels, modify subsequent doses of short acting insulin during the day. Those with type 1 diabetes need to test their urine for ketones if blood glucose is high and they feel unwell.
Patients with gastrointestinal upset who are not eating, but who feel well and continue their usual activities, may need to reduce their insulin (especially quick acting insulin) to avoid hypoglycaemia.
In all cases the underlying cause should be identified and treated and the doses of insulin and oral hypoglycaemic agents should be reviewed.
The Australian Diabetes Educators Association has developed guidelines and patient information on sick day management. Patient information is also available from State and Territory Diabetes Organisations.
8 Hyperglycaemic emergencies • Look for an underlying cause – sepsis, myocardial infarct.
• Correct extracellular fluid deficit and then slowly correct water
depletion and hyperglycaemia.
• Monitor plasma glucose, sodium and potassium closely.
• Transfer to a specialist unit if possible.
Hyperglycaemic emergencies have a significant mortality. They are preventable in people known to have diabetes and their occurrence in this group signifies a major breakdown in medical management.
It is essential that sick day protocols are understood by patients and their carers and that a knowledgeable resource person be contactable at all times (eg: the patient's general practitioner or associate, endocrinologist, diabetes resource centre).
Adequate early management of sick patients with either type 1 or type 2 diabetes will prevent hyperglycaemic emergencies. Therefore many cases will be in patients with previously undiagnosed diabetes.
Diabetic ketoacidosis An absolute insulin deficiency results in:• Increasing hepatic glucose production• Osmotic diuresis and dehydration, potassium and phosphate depletion• Increasing peripheral lipolysis. The liver, in the absence of insulin, converts fatty acids into ketoacids which cause the acidosis.
Signs of diabetic ketoacidosis include dehydration, hyperventilation, ketotic breath, disturbed conscious state and shock.
Also check for signs of some precipitating factors such as urinary tract infection, myocardial infarction, pneumonia.
Wherever possible the patient should be managed in a specialist endocrine unit. In remote rural practice this may not be possible. In this situation it is advisable to contact the most appropriate diabetes resource person for advice while starting treatment straight away.
52 Diabetes Management in General Practice The general outline of management is: Initial investigations
Arterial blood gases (venous in children) Electrolytes and renal function Urine glucose, ketones, microscopy and culture Frequent observation
Clinical and biochemical status. For example:
½ hourly: BP, pulse, urine output capillary blood glucose electrolytes especially potassium Fluids and electrolytes
Most patients have a deficit of several litres (40 to 80 ml/kg). Calculate deficit plus
continuing requirements for the next 24 hours and give about ⅓ of this in the first 5–6 hours. Normal (0.9%) saline is suitable.
As long as the plasma potassium is not very high (eg: above 6 mmol/L) start replacement (eg: ½–2 g, 6–26 mmol per hour) and measure levels and adjust the dose at least 2 hourly.
An intravenous bolus of 0.15 units/kg neutral insulin.
An infusion of neutral insulin 100 units/litre saline is commenced.
Run 100 mls through the line before connecting to the patient to saturate insulin binding to the giving set. If a syringe pump is available add 50 units of neutral insulin to 50 ml of saline and flush the giving set. Commence the infusion at 0.05 to 0.15 units per kg per hour and adjust the dose depending on glycaemia (usual rates are 0.5–6 units per hour for a 70 kg adult).
When blood glucose levels fall below 15 mmol/L set up a 5% dextrose infusion (50–100 ml per hour) and make appropriate adjustments to other i/v fluids.
Diabetic ketoacidosis can be complicated by severe infection, arterial thrombosis, profound shock and lactic acidosis and cerebral oedema. Once treatment is initiated (unless the acidosis is mild and response rapid) transfer the patient to a specialist unit.
Hyperglycaemic emergencies 53 Hyperosmolar non-ketotic coma In type 2 diabetes insulin deficiency is not absolute. Hyperglycaemia and osmotic diuresis occur but lipolysis and ketosis are not major features. Extreme hyperglycaemia develops because of increased hepatic glucose production and decreased peripheral glucose utilisation and because of the fluid losses caused by the osmotic diuresis. Although there is extracellular fluid and sodium depletion plasma sodium levels may be increased because of the larger depletion in total body water. The depletion of the total body water leads to the hyperosmolality of body fluids reflected by the extreme hyperglycaemia and increased plasma sodium. This hyperosmolar state affects consciousness and may cause coma. Hence the name hyperosmolar non-ketotic coma.
The priority is to correct extracellular fluid volume and then slowly correct the hyperglycaemia (with insulin) and water deficit (with low sodium fluids eg: 5% dextrose or 4% dextrose and ¹⁄₅ normal saline). Rapid correction of the hyperosmolar state is dangerous. Monitor extracellular fluid status and plasma glucose and plasma sodium.
Blood glucose meters will not register very high glucose levels so access to a laboratory is necessary to monitor the correction of hyperglycaemia as well as to monitor sodium and potassium levels. Signs of hyperosmolar coma include severe dehydration, disturbed consciousness, coma and shock. Also check for signs of some precipitating factors such as urinary tract infection, pneumonia, myocardial infarction or stroke.
Wherever possible the patient should be managed in a specialist endocrine unit. In remote rural practice this may not be possible. In this situation it is advisable to contact the most appropriate diabetes resource person for advice whilst starting treatment straight away.
The general outline of management is: Electrolytes and renal function Urine glucose, ketones, microscopy and culture 54 Diabetes Management in General Practice Frequent observation
Clinical and biochemical status. For example:
½ hourly: BP, pulse, urine output capillary blood glucose (when registering on the meter) 2 hourly: electrolytes especially sodium and potassium
Fluids and electrolytes
Most patients have a deficit of many litres (60 to 100 ml/kg). Initially normal
(0.9%) saline is suitable to replete the extracellular volume (eg: 3–5 litres over 5–6 hours). Thereafter fluid replacement should be guided by:• Signs of extracellular volume – to guide administration of normal saline• Measures of a body osmolality (measured or roughly calculated: 2 x Na + G) to guide administration of low sodium fluids.
As long as the plasma potassium is not very high (eg: above 5 mmol/L) start replacement (0.5–1 gram, 6–13 mmol/L per hour), measure levels and adjust the dose at least 2 hourly. Insulin
An intravenous bolus of 0.15 units/kg neutral insulin.
An infusion of neutral insulin 100 units/litre saline is commenced. Run 100 mls
through the line before connecting to the patient to saturate insulin binding to the giving set. If a syringe pump is available add 50 units of neutral insulin to 50 ml of saline and flush the giving set. Commence the infusion at 0.05 to 0.15 units per kg per hour and adjust the dose depending on glycaemia (usual rates are 0.5–2 units per hour for a 70 kg adult).
When blood glucose levels fall below 15 mmol/L set up a 5% dextrose infusion (50–100 ml per hour) and make appropriate adjustments to other i/v fluids.
Hyperosmolar coma can be complicated by severe infection, arterial thrombosis, profound shock and lactic acidosis and cerebral oedema. Once treatment is initiated (unless the hyperglycaemia is mild and response rapid) transfer the patient to a specialist unit.
Many hospitals now have an Indigenous Hospital Liaison Officer or equivalent. Contacting that person may assist in accessing acute hospital care for Aboriginal and Torres Strait Islander patients.
Hyperglycaemic emergencies 55 complicating management These may occur independently from the diabetes itself eg: intercurrent illness or may result from the diabetic process eg: macrovascular disease or microvascular disease with nephropathy, retinopathy and neuropathy.
Diabetes is an independent risk factor for both macro and microvascular disease.
Improved glycaemic control has been shown to reduce long term microvascular complications. Control of hypertension also reduces microvascular complications.
Reduction in macrovascular complications may depend on glycaemic control (shown for metformin) but clearly depends on modification of other risk factors such as smoking, hypertension and dyslipidaemia.
Calculation of absolute risk will identify those people where especially active intervention and risk factor monitoring are indicated (absolute 10 year myocardial infarct risk >15%). The National Heart Foundation website provides a simple assessment tool (www.cvdcheck.org.au). Macrovascular disease • Arterial disease is a major cause of mortality and morbidity in
people with diabetes.
• There is a 2–6 fold excess compared with the non-diabetic population.
• Risk factor management is essential – especially smoking, blood
pressure, lipids and glycaemia.
• Unless there are contraindications, prophylactic aspirin
(75–325 mg/d) should be considered.
Diabetes is a major risk factor for the development of atherosclerosis of the major vessels especially coronary and aorto-ilio-femoral systems. These in turn are the major cause of premature death in people with type 2 diabetes. It should be remembered that the incidence of cardiovascular disease is especially increased in women with diabetes.
Management of other risk factors eg: hypertension, dyslipidaemia and smoking will reduce the risk of developing macrovascular disease.
56 Diabetes Management in General Practice Atypical presentations occur most commonly in the elderly and in women with diabetes, but cardiovascular disease is high in the differential diagnosis in any person with diabetes presenting with a medical problem.
The high prevalence of risk factors for cardiovascular disease and of existing disease makes it likely that preventive strategies such as low dose aspirin (eg: 75–325 mg per day) will be beneficial. Note that low dose aspirin does not interfere with oral hypoglycaemic agents and is not contraindicated in most forms of retinopathy. Other antiplatelet agents may be appropriate for patients who have had vascular events (eg: clopidogrel, dipyridamole).
Among the lifestyle related factors, smoking makes the largest contribution to the
absolute risk of macrovascular complications for people with diabetes. The added risk from smoking is greater than in people without diabetes. There is evidence that minimal interventions in the general practice setting can improve cessation rates. The diagnosis of diabetes is often a crisis for people and offers an opportunity to bring about cessation of smoking.
The general practitioner can assist people to quit in the following ways:• Ask about and document smoking habits• Assess stage of readiness and nicotine dependence• Advise to quit and set a date• Assist with information about the QUIT program, nicotine replacement and other pharmacologic therapy • Arrange follow up.
The Royal Australian College of General Practitioners' SNAP (Smoking, Nutrition, Alcohol and Physical activity) guide outlines a general practitioner-friendly smoking cessation intervention. The guide is available at www.racgp.org.au. The QUIT website is also useful (see Internet Resources on page 89). Smoking is more prevalent among Indigenous Australians than the general population. Indigenous Australian adults over 18 years (in every age group) are twice as likely to be current smokers than non-Indigenous (51% versus 24% respectively).
Factors complicating management 57 • Blood pressure control reduces macro and
• Non pharmacological measures should be tried first.
• Preferred initial pharmacological agents are ACE inhibitors or
Angiotensin Receptor Antagonists (ARAs) for most patients.
• To achieve BP targets, combination therapy is often required.
The presence of hypertension in the person with diabetes is an independent contributory risk factor for:• Macrovascular disease: coronary, cerebral and peripheral• Retinopathy• Nephropathy.
Early detection, active treatment and frequent review are essential if morbidity is to be reduced. The general practitioner should aim for lower blood pressure levels in people with diabetes because their blood vessels (both macro and micro) are more susceptible to hypertensive damage (target ≤130/80 mmHg).
• Non-pharmacological treatment, especially maintenance of ideal weight, regular exercise and minimisation of salt and alcohol in the diet, should be emphasised.
• Based on evidence of their effects on renal function, ACE inhibitors and ARAs are preferred drugs for the control of blood pressure in people with diabetes. ACE inhibitors and ARAs have a beneficial effect on renal and • ARAs have a role for people with micro or macro albuminuria.
• Both lying and standing blood pressure must be assessed.
• Checking the blood pressure before the morning dose assesses whether blood pressure control is maintained at trough levels of medication.
Reliable ambulatory blood pressure monitors are available and self-monitoring by patients can provide useful information on blood pressure profiles over the 24-hour period. Such monitoring should be considered in those with suspected ‘white coat' hypertension or who are resistant to therapy.
People with diabetes with autonomic neuropathy are particularly prone to orthostatic hypotension. It may be preferable to accept some hypertension rather than have the person suffer (or fall) with postural hypotension.
58 Diabetes Management in General Practice Getting to target BP (≤130/80; <125/75 if proteinuria >1 g/d present)
Step 1: Healthy eating, physical activity, weight control
Step 2: ACE inhibitor or ARA
Step 3: ACE inhibitor and diuretic
Step 4: Beta-blocker
Produce good control with generally no postural symptoms and no alteration in lipid
profile or glucose tolerance. ACE inhibitors are one of the first line medications in the treatment of moderate to severe hypertension in patients with diabetes.
ACE inhibitors and ARAs can both reduce renal function in patients with renal arterial stenosis or diffuse renovascular disease and it is wise to check plasma potassium and creatinine approximately one week after starting treatment.
ACE inhibitors/ARAs should not be prescribed together since there is no extra benefit but more side effects.
Thiazide diuretics are established agents with a place in early management
of mild hypertension. Low doses (eg: hydrochlorothiazide 12.5 mg/d or indapamide 1.25/2.5 mg/d) have few metabolic side effects.
May mask symptoms of hypoglycaemia and cause hyperglycaemia. They may also
adversely affect the lipid profile, reducing HDL–C and increasing triglycerides. Cardioselective beta-blockers are preferable eg: atenolol, metoprolol.
Have no adverse effects on glucose tolerance or lipid profile.
Diltiazem and verapamil affect cardiac output and the dihydropyridines
(eg: amlodipine) reduce peripheral resistance. Side effects include constipation. The vasodilating dihydropyridines can cause troublesome flushing, peripheral oedema, tachycardia and worsening of angina. Long acting or sustained release preparations are preferred.
Can cause orthostatic hypotension but otherwise is a safe vasodilator in people
with diabetes. It is not recommended in the elderly or patients with autonomic symptoms or cardiac failure.
Factors complicating management 59 Centrally acting agents
Occasional y a central y acting sympatholytic (eg: alphamethyldopa, clonidine or
moxonidene) is useful where beta-blockers cause problems or are contraindicated. However depression, postural hypotension and erectile dysfunction are common side effects.
The Aboriginal and Torres Strait Islander population has a much higher risk of developing cardiovascular (CV) disease and an earlier age of onset than the general Australian population. Ischaemic heart disease (also known as coronary heart disease) is a major contributor to mortality and morbidity in this population. There is also evidence that hypertension is more common, is present from a young age, and often unrecognised in the Aboriginal and Torres Strait Islander population.
• Management of dyslipidaemia is important.
• Non pharmacological measures should be tried first.
• Preferred agents are HMGCoA reductase inhibitors, ezetimibe and
resins for hypercholesterolaemia and fibrates for
Dyslipidaemia is common in patients with diabetes and is an independent risk factor for the macrovascular complications of diabetes. It is therefore important to identify and treat dyslipidaemia.
Often poor control with persistent hyperglycaemia results in hypertriglyceridaemia. The triglyceride level will often drop to acceptable levels when adequate control of weight, diet and glycaemia is achieved. Cholesterol levels will often fall with weight reduction and metabolic control of diabetes. Fish oils (Ω–3 polyunsaturated oils) in doses of 5 g/day lower triglyceride levels but high doses (>3 g/d) can worsen glycaemic control and increase haemorrhagic risk.
The dietary management of hypercholesterolaemia is similar to that of diabetes. The diet should be low in cholesterol, saturated, trans and total fat. However, special emphasis should be put on reducing the intake of total, saturated and trans fats in patients with diabetes and hypercholesterolaemia.
If dietary measures fail after 3–6 months, pharmacological treatment should be instituted. The usual first line medications for isolated hypercholesterolaemia are HMGCoA reductase inhibitors (statins). Adherence is good and statins are extremely effective. Bile acid sequestrant resins (cholestyramine or colestipol) are 60 Diabetes Management in General Practice also reasonable choices for isolated hypercholesterolaemia because of their proven long term safety. Ezetemibe (10 mg, available on PBS streamlined authority script for eligible patients) is a once daily oral medication that also reduces cholesterol absorption. Combining HMGCoA reductase inhibitors and agents reducing cholesterol absorption can be very effective. As the resins may impair absorption of oral hypoglycaemic agents, care should be exercised to separate the time at which the two classes of medication are taken by at least one and a half hours. A pharmaceutical preparation of W3 fatty acids is TGA approved for secondary prevention in type 2 diabetes but is not subsidised by the PBS.
Treatment when both cholesterol and triglycerides are raised should be a statin and/or a fibrate (fenofibrate or gemfibrozil) first depending on the lipid subfractions levels. Combining a fibrate and a statin can cause muscle damage (less so with fenofibrate than gemfibrozil) and should only be considered after specialist consultation. Combining a fibrate with ezetimibe (contraindicated in patients with gall bladder disease) or a resin might be an alternative.
There is some evidence that there is a higher rate of dyslipidaemia in the Aboriginal and Torres Strait Islander population than in the general Australian population. It is important to note that the PBS guidelines include a lowered threshold for prescription of hypolipidaemic medications to Aboriginal people with diabetes. Aboriginality is itself a recognised risk factor for CVD, decreasing the thresholds for initiating medical management of other risk factors, such as hypertension and hyperlipidaemia. PBS guidelines for prescribing lipid lowering drugs in individuals
(Private scripts can be provided for patients who do not meet the PBS criteria)
Lipid criteria (fasting plasma levels)
Diabetes in individuals ≥60 years oldDiabetes with microalbuminuria Treat at any cholesterol level Diabetes in Aboriginal/Torres Strait Islander individuals Diabetes not otherwise included Treat if TC* >5.5 mmol/L * TC = Total cholesterol Nicotinic acid can be added to either schedule but referral may be indicated if the above therapies are not successful. Nicotinic acid can increase glucose intolerance.
Factors complicating management 61 Targets recommended by the National Heart Foundation for people with diabetes (considered at high risk of CVD) are: National Heart Foundation targets
More active treatment may be indicated in people with existing coronary heart disease eg: LDL-C <2.0 mmol/L.
• Microalbuminuria gives early warning of renal damage –
check at annual review.
• Monitor plasma creatinine to estimate changes in GFR.
• Microalbuminuria is an indicator of high cardiovascular risk. Check
other risk factors.
• Control of blood glucose and blood pressure reduces renal damage.
• Watch for asymptomatic urinary tract infections.
Proteinuria is the hal mark of diabetic nephropathy. The appearance of proteinuria during the routine review of patients with diabetes is common. The time of onset of proteinuria and the rate of increase is variable. However, once clinical proteinuria occurs (dip stick positive, >500 mg/L) progressive renal damage is likely. The magnitude of proteinuria (ie: all proteins in the urine) is more than albuminuria (ie: the albumin component). Thus 500 mg/L of proteinuria is roughly equivalent to 300 mg/L of albuminuria.
Initial y intermittent low grade proteinuria occurs (microalbuminuria, 20–200 µg/min). At this stage control of blood pressure and glycaemia may stabilise renal function.
Monitor serum/plasma creatinine to estimate glomerular filtration rate (GFR) at least every twelve months since other causes of renal impairment are common in diabetes. Regular checks of creatinine identify changes in renal function and prompt review. The national adoption of eGFR makes GFR calculation simpler but eGFR is not valid at extremes of body habitus or age and should be interpreted accordingly. Laboratories are encouraged to report estimated GFR ml/min/1.73 m2 body surface area (BSA) – the eGFR. Remember that medication doses should be adjusted according to the total
GFR, not GFR adjusted for BSA.
62 Diabetes Management in General Practice The rate of decline in renal function is accelerated by hypertension. BP control is important to slow progression of renal damage. Lower targets (<125/75) have been set for those with proteinuria >1 g/d. The use of calcium channel blockers instead of beta blockers as step 4 in getting to target BP (page 59) is recommended. The effect of glycaemic control on established renal damage is not clear. However, ideal glycaemic control in patients without renal damage and in those with microalbuminuria delays the onset or progression of renal damage.
The significance of proteinuria (macroalbuminuria) is as follows:• Ten year survival is poor once persistent significant proteinuria is present (ie: 2+ or more). • Proteinuria is a CV risk factor independently from decreased GFR.
• Retinopathy will be present. The patient should be reviewed for retinal problems and have treatment initiated (eg: photocoagulation) if necessary.
• Urine should be regularly screened for infection, a common exacerbating factor in diabetic nephropathy.
• Metformin should not be used in patients with diabetic nephropathy if calculated total GFR is <30 ml/min because of the risk of metformin accumulation and lactic acidosis.
• ACE inhibitors have been shown to slow progression of microalbuminuria and ARAs have been shown to slow progression of micro and macro albuminuria to clinical events.
• 24 hour urine protein excretion should be used to monitor progress and not first voided or timed overnight collections which are used to assess • Referral to a nephrologist or physician experienced in treating renal disease should be considered.
Albumin creatinine ratio (mg/mmol)
Specimen: first voided morning urine
Urinary albumin excretion (µg/min)
Specimen: timed overnight urine collection
Factors complicating management 63 If microalbuminuria is established then the use of an ARA or ACE inhibitor should be considered even in the absence of hypertension.
The STENO-2 study in patients with type 2 diabetes and microalbuminuria showed that more active intervention and improved management of risk factors reduced the incidence of cardiovascular events and renal failure by approximately 50%.
Radiographic contrast media and other nephrotoxic agents may precipitate a sudden deterioration in renal function (see page 69). Tetracyclines may also precipitate sudden deterioration.
The Aboriginal and Torres Strait Islander population has a much higher risk of developing chronic renal disease and end stage renal failure than the general Australian population. In particular, the rising prevalence of diabetes in Aboriginal and Torres Strait Islander people is associated with increased early onset end stage renal disease.
Regular eye review (at least every two years) to detect and
Patients with diabetes are subject to an increased risk of developing several eye complications. For children with onset of diabetes before puberty, eye screening should commence at puberty or earlier in some circumstances. Al other patients should be referred to an ophthalmologist or optometrist at the time of diagnosis. Thereafter, patients should be reviewed at least second yearly and more frequently if problems exist.
Refractive errors occur as the lens shape alters with changes in blood glucose
concentrations. Blurred vision due purely to refractive error corrects with the pinhole test. Correction of refractive errors should be postponed until blood glucose levels are stabilised.
Cataracts occur prematurely in people with diabetes. Patients present with blurred
vision and glare intolerance and may find night vision a particular problem. Interpretation of colours becomes more difficult. Clinically the light reflex is reduced and the fundus may be difficult to see. Treatment is surgical when reduced acuity is affecting lifestyle.
Retinopathy occurs as a result of microvascular disease of the retina. Loss of acuity
not corrected with pinhole testing may be due to retinopathy. Changes seen are:• Dot and blot haemorrhages • Soft and hard exudates• Proliferative blood vessel formation.
64 Diabetes Management in General Practice Maculopathy is difficult to see ophthalmoscopically but is the most common cause
of visual loss in people with diabetes.
Assessment is by direct ophthalmoscopy (with dilated pupils), retinal photography and fluorescein angiography depending on the state of the patient's fundi. General practitioners can monitor patients for diabetic eye disease if they are confident of their technique and examine the eyes through dilated pupils. Initial and then intermittent referral to an ophthalmologist or optometrist is still recommended.
Early diagnosis of retinopathy is essential as early use of laser photocoagulation may delay and prevent visual loss. This early detection can only be achieved by a program of routine screening. Sudden loss of vision may be due to:• Central retinal artery occlusion • Retinal detachment• Vitreous haemorrhage.
Urgent contact with an ophthalmologist is indicated.
The Aboriginal and Torres Strait Islander population has a higher risk of developing cataract than the general Australian population.
• Patients need to know and practise routine foot care.
• Check six monthly for factors predisposing to problems: reduced
circulation or sensation, abnormal foot structure, poor hygiene.
• High risk patients should be reviewed by a podiatrist.
Foot problems result in a large proportion of all amputations and of hospital bed days for diabetes patients. Many problems can be prevented by an organised program of education and supervision.
Prevention is the most important aspect of management of the patient's feet. Early referral to a podiatrist to assess potential abnormal architecture and regular review of neuropathy, vascular disease or deformity are essential.
The foot of a person with diabetes is at risk of damage due to a combination of small and large vessel disease, nerve damage and mechanical instabilities in the foot. Tissue is more susceptible to injury and infection and heals more slowly. A podiatrist may be useful to assess foot architecture at an early stage so that early preventive treatment can be implemented. If vascular disease exists, surgical intervention on the foot can result in poor healing, ulceration and, at worst, gangrene. Such procedures should be carried out by professionals used to working with people with diabetes.
Factors complicating management 65 Ulcers
The most common sites of ulceration are on the plantar surfaces under the
metatarsal heads. Abnormal shearing forces initially cause a bruise under the epidermis. Infection then intervenes, the overlying skin or callus becomes necrotic, sloughs and reveals the ulcer. Complications include cellulitis, thrombotic arterial occlusion and gangrene that may result in amputation.
If the ulcer is superficial, management needs to aim to keep the ulcer moist and to minimise any pressure that might perpetuate the ulcer. If the ulcer is deep, or if cellulitis is present, hospitalisation and bed rest are necessary. Key points of management include:• Specialist endocrine and surgical referral if neuropathy and/or vascular compromise are present • Swabs for culture (including anaerobic) and sensitivity• X-ray to determine boney involvement• Amoxycillin/potassium clavulanate or metronidazole plus cephalexin (Therapeutic Guidelines – Antibiotic 2010).
• Urgent drainage of pus• Post-operative irrigation of wound• Adequate diabetes control• Education and reassessment of footwear.
If the ulcer is not infected and is superficial, care can be ambulatory.
• The general practitioner or a podiatrist should remove excess callus from around the ulcer to facilitate drainage • Patients should be encouraged to keep pressure off the lesion as much as possible to encourage healing • Orthotic aids may redistribute weight bearing forces away from the ulcer site• A contact cast and sometimes orthopaedic intervention for disorganised tarsal joints can help to heal indolent diabetic ulcers.
Neuropathic joint damage
The painful, red, hot, swollen foot is not always infected. It is important to
differentiate between infection and Charcot's arthropathy as the treatment is very different. Damage can occur as a result of minor trauma. Initial x-ray can be normal but serial x-rays will show fracture, new bone formation and joint disorganisation. The metatarsal joints are most commonly affected but the ankle and the metatarso- tarsal joints can also be affected.
An early bone scan will confirm the diagnosis. Differentiation from osteomyelitis or septic arthritis can usually be made by normal white cell count and absence 66 Diabetes Management in General Practice of fever. Treatment is with non-weight bearing crutches, appliances fitted by a podiatrist to reduce further damage and possibly a below knee cast until inflammation has subsided.
The Ischaemic foot
In people with diabetes the disease is usually bilateral and symmetrical.
Clinically leg ischaemia presents as:• Claudication • Gangrene.
Patients with claudication should be encouraged to exercise since this may increase the claudication distance.
Surgical treatment is indicated if there is severe claudication, intractable rest pain or ulceration not responding to medical treatment.
Surgical treatment may consist of:• Sympathectomy: can occasionally help with rest pain but may not improve circulation sufficiently for ulcer healing • Arterial reconstruction if there is a correctable obstruction• Major amputation: for rampant infection, extensive tissue destruction or rest pain not responsive to arterial reconstruction.
Peripheral neuropathy complicating diabetes most commonly affects the sensory and motor nerves of the lower limbs. Early clinical finding include paraesthesia (sometimes painful), decreased pain and touch sensation and impaired deep tendon reflexes. Reduced proprioception occurs later.
• Peripheral neuropathy affects sensory, motor and autonomic nerves.
• Foot care is especially important in patients with neuropathy.
• Check reflexes and sensation at annual review.
Peripheral nerve function should be checked at least yearly in the person with diabetes. The major significance of abnormal peripheral nerve function is its contribution to foot problems. Reduced pain sensation delays attention to trouble spots and significant tissue damage occurs before the patient's attention is aroused. In addition, poor proprioception and muscle atrophy results in abnormal stresses on the foot and joints and in increased propensity for soft tissue and joint damage.
Factors complicating management 67 Patients should understand the importance of appropriate footwear and foot care, establish a regular self-monitoring schedule (including visual checks) and have an action plan to respond to early problems (eg: skin breakdown).
The pain of peripheral neuropathy can be difficult to manage. Antidepressants, anti-epileptics and non steroidal anti-inflammatory medications may help. Local measures may help: desensitisation with capsaicin cream (Zostrix HP) coverage with Opsite and avoidance of pressure from bedclothes at night.
The appearance of peripheral neuropathy should prompt review and consideration of causes other than diabetes. Discomfort may be an incentive to improve metabolic control. Regular podiatric review needs to be considered. Alcohol consumption needs to be assessed and reduced or stopped if excessive.
Motor neuropathy sometimes occurs with muscle wasting, weakness and abnormalities of gait. This can contribute to foot problems by altering the biomechanics of the ankle and foot.
Autonomic neuropathy may result in:
• Orthostatic hypotension
• Impaired gastric emptying
• Delayed/incomplete bladder emptying
• Erectile dysfunction and retrograde ejaculation in males
• Reduced vaginal lubrication with arousal in women
• Loss of cardiac pain, ‘silent' ischaemia or infarction
• Sudden, unexpected cardio-respiratory arrest especially under anaesthetic
or treatment with respiratory depressant medications • Difficulty recognising hypoglycaemia.
Management of people with diabetes with these problems should include a team approach involving relevant specialist medical and allied health professionals.
Problems with medications • Review medication adherence as part of the annual cycle of care.
• Polypharmacy is common and drug interactions can be
dangerous. Consider a Home Medicines Review.
Non-adherence is common and may be a barrier to achieving treatment targets.
Consider simplifying treatment schedules and limiting the number of medications and medication taking occasions. The RACGP guide Putting Prevention into Practice 68 Diabetes Management in General Practice also provides some strategies to address patient adherence on pages 24–26. The full reference for the guide is available at http://www.racgp.org.au/guidelines/greenbook.
Important drug interactions and side effects
People with diabetes will often be taking many hypoglycaemic medications and will require
further prescription and non-prescription agents. Some drug interactions are dangerous and special care is required in older patients and those with autonomic neuropathy. In addition to pharmacological knowledge, pharmacists have skil s in patient care and dosage aids which enhance patient compliance and understanding. Assessment of the person's understanding of their medicines and devices, and how well these are being used, can be undertaken in a Home Medicines Review.
Hypoglycaemia (especially glibenclamide and glimepiride in older patients and
those with autonomic neuropathy)• affecting sulphonylurea pharmacokinetics: sulphonamides, cimetidine, azole antifungal agents, NSAIDs, fluoxetine, fluvoxamine • causing hypoglycaemia or reducing response: alcohol, beta-blockers, ACE inhibitors, high dose salicylates, perhexiline Hypotension (especially in older patients and those with autonomic neuropathy)
• anti-depressants, nitrates, phosphodiesterase inhibitors
• imaging procedures: standard (non-low ionic) radiocontrast agents or
causing dehydration • non-steroidal anti-inflammatory drugs (NSAID), ACE inhibitors, ARAs • colonic preparation: dehydration, Fleet (hyperphosphataemia)
• ACE inhibitors, ARAs, NSAIDs, potassium sparing diuretics,
potassium supplements, non-selective beta-blockers Rhabdomyolysis
• statin and/or fibrates, medications affecting statin clearance: diltiazem,
clarithromycin, erythromycin, azole anti fungals, fluvoxamine, fluoxetine, grapefruit juice Refer also to page 39 for glycaemic effects of non-diabetes medications.
Complementary medicines Predictable positive and negative interactions between complementary medicines and prescribed diabetes medications may be variable, as there is little formal assessment of many of these products. Factors complicating management 69 Recognised issues from observations include:
• Hypoglycaemic effect: From fenugreek, gymnema, bitter melon, chromium,
zinc. Ginseng has at least four in-vivo clinical trials supporting defined • Hypertension: Agents such as liquorice may cause raised blood pressure in
people with diabetes with cardiac and/or renal dysfunction plus deleterious effects of decreasing serum potassium.
• Hypotension: In the presence of renal impairment and hypertensive
management, the following commonly used agents appear to have case reports of concern leading to or aggravating hypotension: andrographis, astragalus, bilberry, cat's claw, CoQ 10, dan shen, dang gui, ginkgo.
• Hyperlipidaemia: Omega-3 fish oil supplementation may have positive mortality
benefits in patients at high risk of cardiac mortality including type 2 diabetes.
• Hypertriglyceridaemia: Though some benefit from niacin has been shown, liver
enzyme abnormalities and hyperglycaemic effects may occur at effective dose.
The National Prescribing Service (NPS) has compiled a guide to medicines information resources relevant to Australian health professionals. This list is available at www.nps.org.au/medicines_information_guide. Interactions can be checked by searching these resources, however the NPS does not warrant their completeness or accuracy.
70 Diabetes Management in General Practice 10 Diabetes and reproductive • Glycaemic control is important before and during pregnancy.
• Specialist endocrine and obstetric care is indicated.
Women with diabetes are more prone to the complications of pregnancy. In addition, pregnancy may accelerate complications of diabetes. There are also increased risks to the well being of the newborn. There is a risk of congenital abnormalities and first trimester spontaneous abortions are increased, probably due to inadequate metabolic control during the first eight to ten weeks of pregnancy. It is therefore important to: • ensure reliable contraception before pregnancy • ensure good metabolic control before becoming pregnant and throughout all stages of pregnancy.
Once pregnancy is diagnosed in a woman with diabetes, she should be managed, if possible, by an obstetrician together with a physician specialising in diabetes. Many of the complications in the later stage of pregnancy can be minimised by ideal metabolic control, close obstetric monitoring and prompt intervention. Proliferative retinopathy may be worsened in pregnancy and if present, should be treated beforehand. Stable background retinopathy is not a contraindication to pregnancy. Similarly diabetic nephropathy can deteriorate in pregnancy and there is a high incidence of pregnancy induced hypertension and pyelonephritis. In general the presence of complications of diabetes is not an indication for termination of pregnancy. The patient must be counselled with respect to risks, treatment options and prognosis.
A few brief points:• The time when the patient requests contraception is appropriate for discussion of long term family planning. When pregnancy is planned, discuss the need for metabolic control, the use of folate and iodine supplements and the outlook for • In general, oral hypoglycaemic agents are not used during pregnancy because of potential ill effects on the fetus. If a woman on an oral agent is trying to become pregnant she needs to consider changing to insulin.
• Encourage couples to have their children early when the likelihood of complications from diabetes is less.
• When pregnancy is being considered, check the degree of control and for retinopathy or nephropathy. A review by a specialist physician and ophthalmologist is usually helpful.
Diabetes and reproductive health 71 • The outlook for pregnancies in patients with glycaemic control and managed in tertiary institutions is very good.
Aboriginal and Torres Strait Islander women are at high risk of having or developing diabetes during pregnancy. Ideally they would check that their blood glucose level is normal before stopping contraception and have early screening for gestational diabetes.
10.2 Gestational diabetes Al pregnant women should be screened between 26 and 28 weeks
gestation with a non-fasting modified glucose tolerance test. This can be
done using a 50 g or 75 g load and plasma glucose taken 1 hour after the
load. Women whose levels are >7.8 mmol/L or 8.0 mmol/L respectively
should have a formal (fasting) 75 g oral glucose tolerance test (OGTT).
Pregnancy is diabetogenic in those with a genetic predisposition. Routine screening does not obviate the need for earlier testing if clinical y indicated (eg: glycosuria at 12 weeks gestation, family history, previous gestational diabetes, poor obstetric history).
Women whose oral glucose tolerance test confirms gestational diabetes (fasting ≥5.5; 2 hours ≥8.0 mmol/L) or frank diabetes should be managed by an obstetrician and physician specialising in this condition, wherever possible. The follow-up of these women is important. A glucose tolerance test at three months post partum will usually show reversion to a normal state. However, 10% to 50% of women who have had gestational diabetes will have type 2 diabetes within five years and the prevalence steadily increases with time. Women who have had gestational diabetes should be encouraged to exercise regularly, to maintain an optimal weight and to be tested every 1–2 years. If a woman is planning another pregnancy she needs to check for diabetes before stopping contraception and check again at 12 and 26 weeks gestation.
Women who have a history of gestational diabetes should have regular screening: • All women with previous gestational diabetes to be offered testing for diabetes with a 75 g OGTT 6–8 and 12 weeks after delivery.
• Repeat testing should be performed every 1–2 years among women with normal glucose tolerance and the potential for further pregnancies.
• If no further pregnancy is planned, fol ow-up testing should be performed every 1–2 years for women with normal glucose tolerance and the potential for further pregnancies and every 3 years if pregnancy is not possible. More frequent re-testing depends on the clinical circumstances (eg: ethnicity, past history of insulin treatment in pregnancy, recurrent episodes of gestational diabetes).
72 Diabetes Management in General Practice Aboriginal and Torres Strait Islander women are a high risk group and should be tested for gestational diabetes at 12 weeks as well as 26–28 weeks. Those women who develop gestational diabetes should be offered tests for diabetes at 6–8 weeks and at 12 weeks after delivery as well as 1–2 yearly thereafter.
10.3 Contraception The combined oral contraceptive pill is usually the best option.
In women of reproductive age with type 2 diabetes, it is important to take a menstrual history as some of these women may also have polycystic ovarian syndrome. Treatment with metformin or a glitazone for their diabetes may restore the menstrual cycle and fertility.
Although there are theoretical arguments against the use of the combined oral contraceptive in patients with diabetes (eg: oestrogen may cause hyperglycaemia) overall reliability and safety make it a good choice.
The progesterone-only pill has theoretical advantages, but is less reliable and can be associated with troublesome spotting intermenstrually. The etonogestrel implant provides greater reliability with 3 years of continuous contraception. As with other progesterone only contraceptives, irregular bleeding can occur. Depot medroxyprogesterone acetate may increase weight and glucose levels but is a reliable and safe form of contraception.
An intra-uterine device (IUD) may be considered in women at ‘low risk' for complications (ie: parous, older women with a stable single partner relationship). The risk of infection is higher in women with diabetes, especially if control is not optimal.
Barrier methods may be effective, but the risk of pregnancy is greater than with the above methods.
Permanent sterilisation is an attractive option if no (or no more) children are wanted. This is especially so in a woman with diabetes given the risks of continuing reversible contraception and the risks of pregnancy itself.
10.4 Hormone replacement therapy There are no data supporting the use of hormone replacement therapy
for primary prevention in postmenopausal women with diabetes.
Hormone replacement therapy (HRT; also known as hormone therapy) should not be recommended to women with diabetes for primary or secondary prevention of Diabetes and reproductive health 73 ischaemic heart disease. Cardiovascular event rates may be increased and there is a significantly increased risk of thrombo-embolic events. There are currently no data to support the use of HRT in primary prevention of cardiovascular disease in women with diabetes.
10.5 Sexual problems Erectile problems occur in up to 50% of men with diabetes.
Inquire at annual review.
Men with diabetes may suffer from erectile dysfunction. This may occur acutely during periods of high blood glucose or chronically.
It is important to inquire about this in the annual screening because the prevalence in men over 40 years old with diabetes may be as high as 50%.
Failure to achieve erection may be due to psychological causes, macrovascular disease or pelvic autonomic neuropathy. An organic cause is more likely when there are other macro or microvascular complications.
It is important to differentiate psychogenic from organic erectile dysfunction. Usually inquiring about spontaneous erections while asleep or in non-sexual situations will help. Psychogenic erectile dysfunction requires counselling and behavioural therapy. Patients with organic erectile dysfunction should be counselled supportively. Phosphodiesterase inhibitors (sildenafil – Viagra; tadalafil – Cialis; vardenafil – Levitra) starting with a low dose are available for men with erectile dysfunction where he and his partner wish to resume sexual activity. Common side effects are generally mild and relate to vasodilation (flushing, nasal stuffiness). If vasodilating nitrates are used, phosphodiesterase inhibitors can cause catastrophic and life threatening hypotension and are contraindicated. Many of the men will have cardiovascular disease (symptomatic or asymptomatic) and the potential cardiovascular risk of resuming sexual activity needs to be discussed. Other techniques like intrapenile prostaglandin E by injection (Caverject) or vacuum devices may help.
The help of a sympathetic specialist urologist should be sought for those considering penile injection with vasoactive agents (preparations now commercially available) or surgical treatment.
Women with diabetes do not seem to suffer from as much sexual dysfunction as men. Some women with diabetes complain of impairment in vaginal lubrication with arousal, presumably due to pelvic autonomic neuropathy. Explanation and use of lubricants may be useful.
74 Diabetes Management in General Practice • Diabetes is identified as one of the medical conditions that may
impair driving ability.
• Drivers with diabetes must meet certain medical standards.
Whilst many factors contribute to safety on the road, driver health is an important consideration. Therefore, certain criteria must be met by drivers to ensure that their health status does not increase the risk of a crash in which they or other road users may be killed or injured.
National medical standards for drivers of private and commercial vehicles are contained in the Austroads document Assessing Fitness to Drive 2003 to be found at www.austroads.com.au/aftd/index.html. An interim review of these standards is being undertaken and discusses changes to diabetes monitoring. Until this review has been completed, the 2003 standards remain current. Note that these are national standards. It is therefore important to contact the driving authority in individual States and Territories as variations to the national standards do exist.
Unexpected hypoglycaemia is the main hazard for those on glucose lowering medications. People with type 2 diabetes not on hypoglycaemia inducing medication may have their ability to drive safely impaired by sensory or end organ complications, particularly reduced vision and reduced sensation in the feet.
Assessing Fitness to Drive 2003 provides:• Medical criteria for driver capability based on available evidence and expert • Legal obligations of medical practitioners and drivers• General guidelines for managing patients with respect to their fitness to drive• A medical examination pro-forma to help guide the assessment process• A reporting template to guide reporting to the Driver Licensing Authority.
After review medical practitioners can advise that a conditional licence is appropriate.
Further details, including clinical examination pro-forma, medical condition notification form, patient questionnaires and rights and responsibilities of medical practitioners can be found at http://www.austroads.com.au/aftd/index.html Medical standards for licensing – diabetes Private standards: (Drivers of cars,
Commercial standards: (Drivers of
light rigid vehicles or motorcycles unless heavy vehicles, public passenger vehicles carrying public passengers or bulk or bulk dangerous goods vehicles) Diabetes controlled by diet alone
A person with diabetes control ed by A person with diabetes control ed by diet alone may drive without licence diet alone may drive without licence restriction and without notification to the restriction and without notification to the Driver Licensing Authority. They should Driver Licensing Authority. They should be reviewed by their treating doctor be reviewed by their treating doctor periodical y regarding progression of the periodical y regarding progression of the Non-insulin requiring type 2 diabetes mellitus
A person with non-insulin requiring diabetes may drive without licence restriction and without notification to the Driver Licensing Authority, subject to 5 yearly review providing they have no complications as per this publication.
The criteria for an unconditional licence are The criteria for an unconditional licence are NOT met… NOT met…. • if the person has end organ complications • if the person has non-insulin which may affect driving, as per this requiring diabetes mellitus on oral • if the person has ‘defined' A conditional licence may be granted by the Driver Licensing Authority, taking A conditional licence may be granted by into account the opinion of a specialist in the Driver Licensing Authority, taking diabetes or endocrinology, and the nature into account the opinion of the treating of the driving task, and subject to at least doctor/general practitioner, and the nature of the driving task, and subject to • if the condition is wel control ed and the periodic review… patient compliant with treatment, and • if the end organ effects and/or • there is an absence of defined hypoglycaemic episodes are satisfactorily hypoglycaemic episodes as assessed by treated, with reference to the standards in the specialist, the patient has awareness this publication.
(sensation) of hypoglycaemia, and the In the event of a defined hypoglycaemic patient is taking agents that provide the episode occurring in a previously well minimum risk of hypoglycaemia, and controlled person they generally should • there is an absence of end organ not drive for six weeks depending on effects which may affect driving as per identification of the reason for the episode, this publication.
and a specialist opinion. In the event of a defined hypoglycaemic episode being associated with a motor vehicle crash, the Driver Licensing Authority must be notified.
76 Diabetes Management in General Practice Insulin requiring diabetes mellitus (types 1 and 2)
The criteria for an unconditional licence are The criteria for an unconditional licence NOT met… are NOT met… • if the person has insulin requiring • if the person has insulin requiring diabetes mellitus.
A conditional licence may be granted by A conditional licence may be granted by the Driver Licensing Authority, taking into the Driver Licensing Authority, taking account the opinion of the treating doctor/ into account the opinion of a specialist in general practitioner, and the nature of the diabetes or endocrinology, and the nature driving task, and subject to at least two of the driving task, and subject to at least • if the condition is well controlled, and • if the condition is wel control ed and the • there is an absence of defined patient compliant with treatment, and hypoglycaemic episodes and there is • there is an absence of defined awareness of hypoglycaemia sufficient to hypoglycaemic episodes as assessed by stop driving a vehicle, and the specialist, the patient has awareness • there is an absence of end organ (sensation) of hypoglycaemia, and the effects which may affect driving, as per patient is taking agents that provide the this publication.
minimum risk of hypoglycaemia, and In the event of a defined hypoglycaemic • there is an absence of end organ episode occurring in a previously well effects which may affect driving as per controlled person they generally should this publication.
not drive for six weeks depending on In the event of a defined hypoglycaemic identification of the reason for the episode occurring in a previously well episode, and a specialist opinion. In the controlled person they should not drive for event of a defined hypoglycaemic episode a period determined by a specialist. In the being associated with a motor vehicle event of a defined hypoglycaemic episode crash, the Driver Licensing Authority being associated with a motor vehicle must be notified.
crash, the Driver Licensing Authority must be notified.
Ref: ‘New medical standards for drivers' pp 732–736, Australian Family Physician Vol. 32, No. 9 September 2003.
Note: These are national standards. It is important to contact the driving authority in individual States and Territories
as variations do exist.
• Forward planning is the key to safe and enjoyable travel.
• Special insurance may be necessary.
• Australian air security guidelines apply.
• Patients should have a covering letter from their doctor and extra
supplies of food, medication and monitoring equipment.
People with diabetes can travel with safety provided a few extra precautions are taken and the travel is planned. They should arrange a medical consultation at least 6 weeks before the proposed travel to allow time to assess control and alter management as required. Use this visit to check routine immunisation status and other medication conditions.
Australian air authorities stipulate the following security guidelines. If not using an Australian carrier, it is advisable for the patient to check with the chosen airline for applicable security guidelines.
• All diabetes supplies including testing equipment, insulin and glucagon delivery devices (syringes, pen needles and insulin pump consumables) carried on board must be in the hand luggage of the person who has diabetes and whose name appears on the airline ticket. It is advisable to pack extra insulin in checked- • The traveller's name should appear on the insulin and/or glucagon • It is advisable to carry legible prescriptions for all medications. The prescriptions must include the traveller's name, name and type of medication and contact details of attending medical practitioner.
• The National Diabetes Services Scheme (NDSS) card is accepted as primary proof that a person with insulin treated diabetes needs to carry with them their diabetes equipment such as insulin pen, pump, syringes, needles and glucagon kit. Supplementary photographic proof of identity such as a driver's licence may also be requested.
• It is advisable to carry a letter from the attending medical practitioner which outlines medical diagnoses, prescribed medications, if insulin is used and if so, the delivery device/s. The letter must stress the importance of the patient having to carry medications with them and include frequency of dosage. For those using an insulin pump, the letter must stress the need for the pump to be worn at all times.
78 Diabetes Management in General Practice • Australian airline regulations limit the amount of liquids (including aerosols and gels) carried by international travellers in their carry-on baggage. Each container must not exceed 100 ml and must fit into a transparent resealable plastic bag no larger than one litre (approx 20 cm x 20 cm, purchased from the local supermarket). While people with diabetes who need to carry supplies of insulin are exempt, they will be required to present the insulin at the security point and carry proof of their condition and their need for insulin.
• People wearing electronic devices to monitor blood glucose levels or infuse insulin should check with the airline as to whether these devices can be operated Rights of people with diabetes during security check
People with diabetes who use an insulin pump are not required to remove their
pump at the security point. If this is requested by security staff, the person with diabetes has the right to request access to a private consultation room which security staff are required to provide. People with diabetes are also entitled to make this request if discussion about their condition is required.
Those people not using insulin generally have few problems during travel. The stress of travel may increase blood glucose levels slightly. The decreased activity experienced in a long plane trip, together with the amount of food given en route often results in increased blood glucose levels. These return to normal once a more usual lifestyle has been resumed at the destination.
For more information about travel and diabetes, go to http://travelsecure.infrastructure.gov.au and scroll down to ‘special needs'.
13 Diabetes Australia Diabetes Australia is a national body, representing a federation of consumer, health professional and research organisations. It is the national peak body for diabetes in Australia providing a single powerful voice for people living with diabetes, their families and carers. In 2007 Diabetes Australia developed a new strategic focus around five key national priorities to turn diabetes around. These priorities span the full spectrum of the disease: awareness, prevention, detection, management and cure. In collaboration with State and Territory Diabetes Organisations, diabetes health professionals and educators, researchers and health care providers, Diabetes Australia works to minimise the impact of diabetes on the Australian community.
Diabetes Australia represents the interests of people with diabetes and those at risk of developing diabetes. It is a significant financial contributor to research into better treatments for diabetes and the search for a cure, with donations towards research coming from a wide variety of sources. Diabetes Australia is the Australian member of the International Diabetes Federation (IDF) and participates in leading medical symposiums and conferences worldwide.
Working with general practice
The 'Diabetes Management Journal' is published quarterly by Diabetes Australia
as a direct line of communication between Diabetes Australia, general practitioners and health professionals in the field of diabetes management. This ensures that messages on the optimum care for people with diabetes and the latest developments in diabetes management are delivered to front line health care providers. The 'Diabetes Management Journal' is available through professional membership of State and Territory Diabetes Organisations (call 1300 136 588).
State and Territory Diabetes Organisations – how your patients
will benefit from membership
With more than 180,000 members, membership of State and Territory Diabetes
Organisations offers exclusive benefits to people with diabetes and health professionals including product discounts and other special services for a nominal annual subscription fee. Call 1300 136 588 for details.
80 Diabetes Management in General Practice Educational resources from Diabetes Australia
Membership of State and Territory Diabetes Organisations provides access to a wide
range of educational resources including information sheets in different languages, available for free download from www.diabetesaustralia.com.au with links to State and Territory Diabetes Organisations.
Diabetes Australia Canberra ACT 2601 Ph: 02 6232 3800 Fax: 02 6230 1535 Diabetes Australia 81 14 National Diabetes Services What is the NDSS?
The NDSS is an Australian Government Scheme, administered by Diabetes
Australia. The purpose of the Scheme is to deliver diabetes-related subsidised products and information and support services to people diagnosed with diabetes. Products available on the NDSS are blood glucose testing strips and urine testing strips and free pen-needles and syringes. Insulin pump consumables are available on the NDSS to Registrants who meet additional criteria.
The NDSS offers community tailored information programs, focused on improving quality of diabetes care and self management. NDSS Registrants should contact their local NDSS Agent on 1300 136 588 to find out what free services they are entitled to as Registrants of the NDSS.
The role of the general practitioner
Diabetes Australia understands the importance of the initial information provided
by medical practitioners in ensuring that the newly diagnosed are referred to the NDSS. As the first point of contact at diagnosis, general practitioners are in a unique position to improve a patient's capacity to manage their diabetes through registration with the NDSS. Refer to the lift-out card for information to correctly refer patients. Diabetes Australia and the Australian Government would like to see every person diagnosed with diabetes able to receive the very real benefits offered by the NDSS.
NDSS products and services
Diabetes related products and services available on the NDSS include:
• Subsidised blood glucose testing strips and urine testing strips costing the
patient less in co-payment than those available with a prescription • Free syringes and pen-needles for insulin-requiring Registrants• Subsidised insulin pump consumables for eligible Registrants• A range of information and education services.
A Registrant Information Pack is provided at the time of registration on the NDSS. From time to time, Diabetes Australia may also send information to assist Registrants in managing their diabetes and tell them about the NDSS. There are no charges for these services and personal details remain confidential. 82 Diabetes Management in General Practice Who is eligible to register
All Australians who have diabetes (including gestational diabetes) and a Medicare
card are able to benefit from the NDSS, as are some visitors to Australia who have
diabetes and are from a country with a reciprocal health agreement. Eligible persons
can only be registered by a doctor or credentialled diabetes educator.
Over one million people are registered on the NDSS, with new Registrants joining
at a rate of approximately 7,000 per month. It has been estimated that there may
be 50,000 people with diagnosed diabetes currently not registered with the NDSS
and at least another 500,000 with undiagnosed diabetes.
Registration forms are available from www.ndss.com.au or by calling
1300 136 588. Registration is free, easy and only has to be done once.
Access to the NDSS
Once registered with the NDSS, people with diabetes can access the wide range of
products through one of the 3,600 NDSS pharmacies/outlets throughout Australia.
Products can also be mailed out by ordering over the phone, by fax or via the
internet (selected states only).
The NDSS and State and Territory NDSS Agents also provide a range of
information and education services to Registrants.
For more information on the NDSS, including where NDSS products can be
purchased or information and services available through your NDSS agent, go to
There is a difference
Registering with the NDSS does not automatically entitle your patients to
membership with State and Territory Diabetes Organisations. Membership is separate and there is an annual subscription. For details phone your nearest State or Territory Diabetes Organisation on 1300 136 588 or go to www.diabetesaustralia.com.au for a link to your State or Territory.
the national Diabetes Services Scheme (nDSS) is an initiative of the Australian government administered by Diabetes Australia.
National Diabetes Services Scheme (NDSS) 83 15 Royal Australian College of General Practitioners RACGP was established in 1958 to maintain high standards of learning and conduct in General Practice. The Col ege is the respected and national leader in setting and maintaining standards for quality practice, education and research for Australian general practice.
RACGP advocates and promotes high quality diabetes management and care through: • Regular articles in Australian Family Physician. AFP is the most widely read peer reviewed general practice journal in Australia. You can access recent editions of AFP at http://www.
• Advocacy on key issues related to diabetes management.
• Partnership with Diabetes Australia in the production of this handbook, Diabetes Management in General Practice which is updated annually. • Access to an extensive library col ection, with many items available electronical y. • The Col ege's flagship products – Guideline for Preventive Activities in General Practice (the Red Book), Putting Prevention into Practice (the Green Book) and the RACGP SNAP Guide. You can access the latest edition of these resources at http:// 1 Palmerston Crescent Sth Melbourne VIC 3205 84 Diabetes Management in General Practice Further resources (accessed June 2011) Diabetes: Australian facts 2008
National Evidence Based Guidelines for the Management of Type 2 Diabetes Mellitus
National Evidence Based Guidelines on Type 2 Diabetes www.diabetesaustralia.com.au Diabetes Prevention and Management in General Practice: Using the Pen Computer Systems Clinical Audit Tool tabid/351/Default.aspx
Australian Medicines Handbook, 2011 edition
National Prescribing Service — provides information for consumers and health professionals on use www.nps.org.au
www.healthinsite.gov.au healthdirect — 24 hour health advice line Freecall: 1800 022 222 NSW Multicultural Health Communication Service Reality Check — type 1 diabetes network www.realitycheck.org.au
Guidelines for Preventive Activities in General Practice (the red book), 7th edition, 2009
Putting Prevention into Practice (the green book), 2nd edition, 2006 SNAP: A Population Health Guide to Behavioural Risk Factors in General Practice, 2004 Heart Foundation — Managing Lifestyle Risk Factors Australian Type 2 Diabetes Risk Assessment Tool 781/$File/austool4.pdf National Physical Activity Guidelines for Australians Alcohol Guidelines Further Resources 85 Dietary Guidelines for all Australians www.glycemicindex.com Smoking Cessation Guidelines for Australian General Practice — including a desktop guide www.racgp.org.au/guidelines/smokingcessation www.quit.org.au
Aboriginal and Torres Strait Islanders
National Guide to a Preventive Assessment in Aboriginal and Torres Strait Islander Peoples
Travel and Diabetes
Australian Diabetes Educators Association — Guidelines for Sick day Management for people
with Diabetes, 2006 Australasian Podiatry Council — find a podiatrist www.apodc.com.au Optometrists Association Australia — find an optometrist www.optometrists.asn.au
ACCORD Study Group. Long term effects of intensive glucose lowering on cardiovascular outcomes.
N Engl J Med 2010 Mar 3 2008;358:2545-2559. ACCORD Study Group. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med 2010 Apr 29;362(17):1563-1574. ACCORD Study Group. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med 2010 Apr 29;362(17):1575-1585. ADVANCE Collaborative Group, Patel A MacMahon S, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diasbetes. N Engl J Med 2008;358:2560-2572.
VADT Study, Duckworth W, Abraira C, Moritz T, et al. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 2009;360:129-139.
Diabetes Prevention Program Research Group. 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet 2009 Nov 14;374(9702):1677-1686. Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993 Sep 30;329(14):977-986. Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy, the Epidemiology of Diabetes Interventions and Complications (EDIC) study. JAMA 2003;290:2159-2167.
United Kingdom Prospective Diabetes Study Group (UKPDS). Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in people with diabetes. Lancet 1998;352:837-853.
United Kingdom Prospective Diabetes Study Group (UKPDS). Holman RR, Paul SJ, Bethel MA, Matthews DR, Neil HA. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008;359:1577-1589.
See also Internet Resources on page 89. Diabetes Management in General Practice ACE inhibitors/ARAs General practice management Albumin creatinine ratio Gestational diabetes 13, 17, 72
Annual cycle of care Glargine (Lantus) Assessment, initial Glomerular Filtration Rate 16, 27, 56,
Glycaemic control, targets Glycemic index (GI) Glycemic load (GL) Byetta (Exenatide) Goals for management CGMS (Continuous Glucose Monitoring System) Calcium antagonists 24–25, 27,
HMGCoA Reductase Inhibitors Home Medicines Review Centrally acting agents Hormone replacement therapy Complementary medicines 16, 17, 52–55,
16, 20–21, 74
Hyperosmolar non-ketotic coma 58–60, 63, 70
Enhanced Primary Care program Erectile dysfunction 28, 37–39, 48,
Exenatide (Byetta) 19, 26, 45
Initial management 38, 39, 40
Interaction with Phosphodiesterase inhibitors other medications Physical activity LADA (late-onset autoimmune Practice Incentive Program 19, 29, 33
Macro/microvascular 59, 62–63
37–40, 49, 63
Refractive errors 26, 38–39
18, 28, 50
19, 58, 63, 64
National Integrated Diabetes Service Incentive Program (SIP) NDSS (National Diabetes Services Scheme) 58, 62, 63, 71
16, 29, 56, 57
Neuropathic joint damage Statins (HMGCoA Reductase 67–68, 69, 74
26, 37–40, 48
Surgical procedures: management 49 Oral Glucose Tolerance Test Team care arrangements (TCA) Oral hypoglycaemic agents Types of diabetes Treatment algorithm Urinary tract infection Waist circumference 88 Diabetes Management in General Practice Internet resources Aboriginal people
(go to page 51 within pdf ) http://travelsecure.infrastructure.gov.au (scroll down to 'Special Needs') www.dtu.ox.ac.uk (downloadable UKPDS risk engine) * Above websites accessed 4 July 2011 * See also Further Resources on page 85. An electronic version of these guidelines is available on RACGP's website www.racgp.org.au/guidelines.
Also available are the significant clinical changes to the last edition in 2010/11. Any changes after the
printing of this edition and before the next will be available on this website.
For copies of this booklet, contact your local Division of General
Practice. If not able to assist, email email@example.com.
When referring your patients to their State or Territory Diabetes
Organisation, the phone number is 1300 136 588.
Internet Resources 89 Goals for management Encourage all people with diabetes to reach the following goals
for optimum management of their diabetes
Ideal 4.0–6.0 mmol/L (fasting) NHMRC 6.1–8.0 mmol/L (fasting) Total cholesterol
<25 kg/m2 where appropriate Urinary albumin excretion
<20 µg/min (timed overnight collection) <20 mg/L (spot collection) <3.5 mg/mmol: women < 2.5 mg/mmol: men (albumin creatinine ratio) Cigarette consumption
≤ 2 standard drinks (20 g) per day for men Physical activity
at least 30 minutes walking (or equivalent) 5 or more days/week (total >150 minutes/week) Doctors should consider:
– Prophylactic aspirin (75–325 mg) daily unless there are contraindications
– Immunisation against influenza and pneumococcal disease * National Heart Foundation Guidelines NHMRC Evidence Based Guidelines for the Management of Type 2 Diabetes, 2005 ° NHMRC Australian Guidelines to Reduce Health Risks from Drinking Alcohol, 2009 supporting the education programs of Diabetes Australia
Which media set the news agenda: Mass media or/and social media?An independent research report sponsored by iSentia EXECUTIVE SUMMARY Professor Jim Macnamara. PhD, MA, FAMI, CPM, FAMEC, FPRIA Media provide a megaphone for the voice of The popularity of social media and networks such individuals and organisations and mass media – as Facebook, Twitter, YouTube, Flickr, Pinterest