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Epiceram monograph for cps 201

EpiCeram®
Topical therapeutic Skin Barrier Emulsion

PEDIAPHARM INC.
Date of preparation: August 31, 2010 Summary Product Information:
EpiCeram Skin Barrier Emulsion is a steroid-free, fragrance - free, ceramide- dominant
formulation.

Indications:
EpiCeram Skin Barrier Emulsion is to be used to treat dry skin conditions and to manage and
relieve the burning and itching associated with various types of dermatoses, including atopic
dermatitis. EpiCeram Skin Barrier Emulsion helps to relieve dry, waxy skin by maintaining a
moist wound and skin environment, which is beneficial to the healing process.
EpiCeram Skin Barrier Emulsion is contraindicated in persons with known hypersensitivity to any of the components of the formulation. Warnings
EpiCeram Skin Barrier Emulsion does not contain a sunscreen and should always be used in conjunction with a sunscreen in sun exposed areas. In radiation dermatitis and/or in conjunction with ongoing radiation therapy, apply following radiation therapy. Do not apply within 4 hours prior to radiation therapy. Apply twice daily or as indicated by the radiation therapist. After application, a temporary tingling sensation may occur (10 to 15 minutes). Keep this and similar products out of the reach of children. Follow directions for use. If condition does not improve within 10 to 14 days, consult a physician. Precautions and Observations
For the treatment of any dermal wound, consult a physician. • Use EpiCeram Skin Barrier Emulsion only as directed. • EpiCeram Skin Barrier Emulsion is non-toxic; however it is for external use only and should not be ingested or taken internally. • If clinical signs of infection are present, appropriate treatment should be initiated. If clinically indicated, use of EpiCeram Skin Barrier Emulsion may be continued during the anti-infective therapy. • If the condition does not improve within 10-14 days, consult a physician. • EpiCeram Skin Barrier Emulsion does not contain a sunscreen and should always be used in conjunction with a sun screen in sun exposed areas. • In radiation dermatitis and/or in conjunction with ongoing radiation therapy, apply following radiation therapy. • Do not apply within 4 hours prior to radiation therapy. Apply twice daily or as indicated by the radiation therapist. • Following the application of EpiCeram Skin Barrier Emulsion a temporary tingling sensation may occur (10-15 minutes). • Keep this and other similar products out of the reach of children. Mode of action and clinical pharmacology

The stratum corneum is a multilayered tissue composed of flattened anucleated corneocytes embedded in a lipid-enriched extracellular matrix is derived from lipid sheets extruded from the lamellar bodies. Lamellar bodies fuse with the plasma membrane of the granular cell and discharge lipids and enzymes into the extracellular space. Enzymatic processing of the extracellular lipids is required to generate the mature lamellae. The corneocytes with the extracellular lipid surroundings provide the mechanical protection and water regulation of the skin barrier. In patients with atopic dermatitis, this lipid barrier is markedly reduced. EpiCeram is a ceramide-dominant, physiologic, lipid-based emulsion that provides an optimal
3:1:1 ratio of ceramides, cholesterol and free fatty acids to replenish the skin barrier in
atopic skin.
EpiCeram normalizes the skin barrier through multiple proposed mechanisms: • Creation of a barrier to prevent transepidermal water loss • Bulk replenishment of physiologic lipids • Enrichment of high quality of ceramides • Delivery of an optimal ratio of ceramides, cholesterol, and free fatty acids • Formulation is buffered at pH 5.5 In a study designed to assess the efficacy of EpiCeram® in correcting the lipid-biochemical abnormalities in atopic dermatitis (AD), EpiCeram reduced clinical disease severity after 14 and 28 days of therapy (Efficacy of a lipid-based barrier repair formulation in moderate-to-severe paediatric atopic dermatitis, Sugarman, JL, J Drugs in Dermatol. 2009;8(12):1106-1111). The study, a five-center, investigator-blinded, randomized trial, compared EpiCeram® to fluticasone propionate cream (Cutivate®) in 121 patients with moderate-to-severe AD. Primary outcome measures were: 1) Reduction in disease severity, assessed as SCORAD scores; 2) improvement in pruritus; and 3) changes in sleep habits. Results showed that EpiCeram reduced clinical disease severity, decreased pruritus, and improved sleep habits both 14 and 28 days after initiation of therapy. The EpiCeram-treated group did not differ significantly from the fluticasone-treated group by 28 days in terms of SCORAD, pruritus, and sleep habit scores. SCORAD scores decreased 37% and 51% from the baseline at 14 and 28 days respectively (Table 1; p <0.001). Subjective pruritus and sleep habits scores decreased in parallel, and to a comparable extent (Table 1). Both the patients/family self-assessment and IGA scores also demonstrated parallel, highly significant improvement at 14 and 28 days. Based upon changes in SCORAD and IGA scores, there was no statistical difference between the ceramide-dominant, barrier formulation and fluticasone propionate at 28 days (Table 2). Both agents demonstrated significant improvements in pruritus, sleep habits, and patient/family assessment scores at both 14 and 28 days, changes that did not differ significantly from one another. Fluticasone propionate-treated subjects demonstrated significantly faster improvement in SCORAD and IGA scores at 14 days (p<0.05)(Table 2). Thus, with the exception of SCORAD and IGA scores at day 14, the ceramide-dominant barrier formulation and fluticasone propionate cream demonstrated comparable efficacy for moderate-to-severe atopic dermatitis. CLINICAL ENDPOINTS FOLLOWING TREATMENT WITH EPICERAM
Change (%)1
Baseline
PRURITUS2
Baseline
SLEEP HABITS2
Baseline
1 Reduction from baseline; 2 Ten-point scale where 0=none.
STATISTICAL COMPARISONS OF RESPONSES TO EPICERAM AND FLUTICASONE
Mean Reduction from Baseline
SCORAD (0 to 72)
EpiCeram (%)
Fluticasone (%)
Anova p-value: 0.021; Rank sum p-value: 0.081 Anova p-value: 0.134; Rank sum p-value: 0.363 SCORAD: 0 = no evidence of disease
Instructions for Use
Apply in a thin layer to the affected skin areas 2 times per day (or as needed) and massage gently into the skin. If the skin is broken, cover EpiCeram Skin Barrier Emulsion with a dressing of choice. Information to be provided to the patients using EpiCeram: • Patients should use EpiCeram as directed by the physician. EpiCeram is for external topical use only; patients should wash their hands after application. • Patients should not use EpiCeram for any disorder other than that for which it is • EpiCeram is recommended to be used b.i.d. in atopic dermatitis on targeted area as directed by your physician; it can be used as a prophylactic on areas prone to repeated atopic dermatitis. • Should EpiCeram be prescribed along with steroids or a topical immunomodulator, it is recommended to apply EpiCeram on affected areas of the skin just a few minutes before to allow proper penetration. To ensure efficacy of EpiCeram in combination therapy, it should never be mixed with any other product. • EpiCeram should not be mixed on skin with an emollient or moisturizer • Prior to applying EpiCeram after a shower or bath, make sure that the skin is completely Ingredients
Capric Acid, Cholesterol, Citric Acid, Conjugated Linoleic Acid, Dimethicone, Disodium EDTA, E. Cerifera (Candelilla) Wax, Food Starch, Modified Corn Syrup Solids, Glycerin, Glyceryl Stearate, Hydroxypropyl Bispalmitamide MEA (Ceramide), Palmitic Acid, PEG-100 Stearate, Petrolatum, Phenoxyethanol, Potassium Hydroxide, Purified Water, Sorbic Acid, Squalane, Xanthan Gum. Supplied: EpiCeram Skin Barrier Emulsion is available in 50 g tube.
Store at 15°C to 30°C (59° F to 86°F). Do not freeze.
Marketed in Canada by:
Pediapharm, Inc.
Verdun, QC H3E 1A2
Customer service: 1-877-630-5674
Website:

Source: http://pedia-pharm.osci.ca/en/wp-content/uploads/sites/3/2014/03/EpiCeram_Monograph_Aug-31_2010_EN.pdf

Helicobacter pylori infection and the use of nsaids

Best Practice & Research Clinical Gastroenterology Vol. 15, No. 5, pp. 775±785, 2001 doi:10.1053/bega.2001.0234, available online at http://www.idealibrary.com on6 Helicobacter pylori infection and the use of Franco Bazzoli MDLuca De Luca MD Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinico S. Orsola, Italy David Y. Graham* MDDepartment of Medicine, Veterans' A€airs Medical Center and Baylor Col ege of Medicine, Houston, Texas,

Doi:10.1016/j.livsci.2006.11.005

Livestock Science 110 (2007) 214 – 220 Effect of photoperiod on milk yield and quality, and reproduction in dairy goats R. Garcia-Hernandez, G. Newton, S. Horner, Lou C. Nuti ⁎ International Goat Research Center, Prairie View A&M University, Prairie View, Texas, 77446, United States Received 2 May 2006; received in revised form 5 October 2006; accepted 2 November 2006